Global Patent Index - EP 2029157 A4

EP 2029157 A4 20091118 - ABC TRANSPORTER LIGAND

Title (en)

ABC TRANSPORTER LIGAND

Title (de)

ABC-TRANSPORTERLIGAND

Title (fr)

LIGAND DES TRANSPORTEURS ABC

Publication

EP 2029157 A4 20091118 (EN)

Application

EP 07783925 A 20070518

Priority

  • US 2007069243 W 20070518
  • US 80186306 P 20060519

Abstract (en)

[origin: WO2007137163A2] Compositions and methods of using scorpion venom peptide that is a ligand for ABC transporters. One aspect provides a peptide having at least 80% sequence identity to SEQ ID NO: 1. The peptide Is believed to have a molecular mass of about 3.7 kDa and specifically interacts with cystic fibrosis transmembrane conductance regulator. Methods of treating a disorder or symptom of a disorder related to aberrant ABC transporter activity are also provided.

IPC 8 full level

A61K 38/00 (2006.01)

CPC (source: EP US)

A61P 1/12 (2017.12 - EP); A61P 13/12 (2017.12 - EP); C07K 14/43522 (2013.01 - EP US); Y10S 530/855 (2013.01 - EP)

Citation (search report)

  • [XY] WO 03101474 A1 20031211 - TRANSMOLECULAR INC [US], et al
  • [XY] FULLER MATTHEW D ET AL: "Inhibition of CFTR channels by a peptide toxin of scorpion venom.", AMERICAN JOURNAL OF PHYSIOLOGY. CELL PHYSIOLOGY NOV 2004, vol. 287, no. 5, November 2004 (2004-11-01), pages C1328 - C1341, XP002549356, ISSN: 0363-6143
  • [X] ADJADJ E ET AL: "Solution structure of Lqh-8/6, a toxin-like peptide from a scorpion venom--structural heterogeneity induced by proline cis/trans isomerization.", EUROPEAN JOURNAL OF BIOCHEMISTRY / FEBS 15 MAY 1997, vol. 246, no. 1, 15 May 1997 (1997-05-15), pages 218 - 227, XP002549357, ISSN: 0014-2956
  • [T] FULLER MATTHEW D ET AL: "State-dependent inhibition of cystic fibrosis transmembrane conductance regulator chloride channels by a novel peptide toxin.", THE JOURNAL OF BIOLOGICAL CHEMISTRY 28 DEC 2007, vol. 282, no. 52, 28 December 2007 (2007-12-28), pages 37545 - 37555, XP002549358, ISSN: 0021-9258
  • See references of WO 2007137163A2

Designated contracting state (EPC)

AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU LV MC MT NL PL PT RO SE SI SK TR

DOCDB simple family (publication)

WO 2007137163 A2 20071129; WO 2007137163 A3 20080717; EP 2029157 A2 20090304; EP 2029157 A4 20091118; US 2009203598 A1 20090813; US 8106013 B2 20120131

DOCDB simple family (application)

US 2007069243 W 20070518; EP 07783925 A 20070518; US 29988107 A 20070518