EP 2032561 A2 20090311 - DUAL MOLECULES CONTAINING A PEROXIDE DERIVATIVE, THEIR SYNTHESIS AND THERAPEUTIC USES
Title (en)
DUAL MOLECULES CONTAINING A PEROXIDE DERIVATIVE, THEIR SYNTHESIS AND THERAPEUTIC USES
Title (de)
DOPPELMOLEKÜLE MIT EINEM PEROXIDDERIVAT, IHRE SYNTHESE UND THERAPEUTISCHE VERWENDUNG
Title (fr)
MOLECULES DUALES CONTENANT UN DERIVE PEROXYDIQUE, LEUR SYNTHESE ET LEURS APPLICATIONS THERAPEUTIQUES
Publication
Application
Priority
- FR 2007000946 W 20070608
- FR 0605235 A 20060613
Abstract (en)
[origin: WO2007144487A2] The invention concerns dual molecules corresponding to formula (I): in which: - A represents a molecular residue with antimalarial activity of formula (IIa) or (IIIa) or a residue facilitating bioavailability; - B represents a cycloalkyl group potentially substituted, or B represents a bi- or tricyclic group capable of being substituted, or B represents 2 cycloalkyl groups linked together through either a single bond or an alkylene chain; - m and n represent independently of one another 0, 1 or 2; - R<SUB>5</SUB> represents a hydrogen atom, an alkyl, cycloalkyl or C<SUB>1</SUB>-<SUB>3</SUB>-alkylene-cycloakyl group; - Z<SUB>1</SUB> and Z<SUB>2</SUB> represent an alkyl radical, the group Z<SUB>1</SUB> + Z<SUB>2</SUB> + C<SUB>i</SUB> + C<SUB>j </SUB>representing a mono- or polycyclic structure, with one of the Z<SUB>1</SUB> or Z<SUB>2</SUB> being able to represent a single bond; - R<SUB>1</SUB> and R<SUB>2</SUB>, identical or different, represent a hydrogen atom or a functional group capable of increasing hydrosolubility; - R<SUB>x </SUB>and R<SUB>y</SUB> forming together a cyclic peroxide including 4 to 8 links and including 1 or 2 additional oxygen atoms in the cyclic structure, possibly substituted by one or more R<SUB>3</SUB> groups; as a base or a salt to be added to an acid, as a hydrate or solvate, in racemic form, isomers and their mixtures, in addition to their diastereoisomers and their mixtures. Preparation method and use as medications with antimalarial activity.
IPC 8 full level
C07D 405/12 (2006.01); A61K 31/4709 (2006.01); A61P 33/06 (2006.01)
CPC (source: EP KR US)
A61K 31/4709 (2013.01 - KR); A61P 33/02 (2018.01 - EP); A61P 33/06 (2018.01 - EP); C07D 405/12 (2013.01 - EP KR US); Y02A 50/30 (2018.01 - EP)
Designated contracting state (EPC)
AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU LV MC MT NL PL PT RO SE SI SK TR
Designated extension state (EPC)
AL BA HR MK RS
DOCDB simple family (publication)
FR 2902100 A1 20071214; AP 2008004711 A0 20081231; AR 061347 A1 20080820; AU 2007259116 A1 20071221; AU 2007259116 A8 20090430; BR PI0713739 A2 20130618; CA 2665940 A1 20071221; CN 101466706 A 20090624; CR 10469 A 20090226; EA 200970002 A1 20090630; EC SP088958 A 20090130; EP 2032561 A2 20090311; IL 195394 A0 20090803; JP 2009539946 A 20091119; KR 20090029208 A 20090320; MA 30577 B1 20090701; MX 2008015980 A 20090326; NO 20085308 L 20090312; PE 20080335 A1 20080522; TN SN08462 A1 20100414; TW 200817376 A 20080416; US 2012122923 A1 20120517; UY 30413 A1 20080131; WO 2007144487 A2 20071221; WO 2007144487 A3 20080207; ZA 200810012 B 20100526
DOCDB simple family (application)
FR 0605235 A 20060613; AP 2008004711 A 20070608; AR P070102553 A 20070612; AU 2007259116 A 20070608; BR PI0713739 A 20070608; CA 2665940 A 20070608; CN 200780021855 A 20070608; CR 10469 A 20081127; EA 200970002 A 20070608; EC SP088958 A 20081211; EP 07788851 A 20070608; FR 2007000946 W 20070608; IL 19539408 A 20081119; JP 2009514836 A 20070608; KR 20087030376 A 20081212; MA 31552 A 20090106; MX 2008015980 A 20070608; NO 20085308 A 20081218; PE 2007000739 A 20070612; TN SN08462 A 20081117; TW 96121347 A 20070613; US 33263308 A 20081211; UY 30413 A 20070613; ZA 200810012 A 20070608