Global Patent Index - EP 2037954 A4

EP 2037954 A4 20110914 - METHOD FOR MODULATING THE PHARMACOKINETICS AND METABOLISM OF A THERAPEUTIC AGENT

Title (en)

METHOD FOR MODULATING THE PHARMACOKINETICS AND METABOLISM OF A THERAPEUTIC AGENT

Title (de)

VERFAHREN ZUR MODULATION VON PHARMAKOKINETIK UND METABOLISMUS EINES THERAPEUTIKUMS

Title (fr)

MÉTHODE POUR MODULER LES PROPRIÉTÉS PHARMACOCINÉTIQUES ET LE MÉTABOLISME D'UN AGENT THÉRAPEUTIQUE

Publication

EP 2037954 A4 20110914 (EN)

Application

EP 07812192 A 20070619

Priority

  • US 2007071510 W 20070619
  • US 81522306 P 20060620

Abstract (en)

[origin: WO2007149827A2] This invention is a method for enhancing the activity of a therapeutic agent comprising the administration of the agent in combination with an enzyme, whereby a metabolic pathway of the therapeutic agent is counteracted and the agent's pharmacokinetics and metabolism are modulated.

IPC 8 full level

A61K 38/43 (2006.01); A61K 38/44 (2006.01); A61K 38/46 (2006.01)

CPC (source: EP)

A61K 38/47 (2013.01); A61K 45/06 (2013.01); C12Y 302/01031 (2013.01)

Citation (search report)

  • [X] US 5279824 A 19940118 - SAWYER ROY T [GB], et al
  • [X] WO 2006042056 A2 20060420 - UNIV OHIO STATE [US], et al
  • [X] US 2004071685 A1 20040415 - HOUSTON DEVIN [US], et al
  • [X] US 2005260186 A1 20051124 - BOOKBINDER LOUIS H [US], et al
  • [X] HOUBA P H ET AL: "Pronounced antitumor efficacy of doxorubicin when given as the prodrug DOX-GA3 in combination with a monoclonal antibody beta-glucuronidase conjugate.", INTERNATIONAL JOURNAL OF CANCER. JOURNAL INTERNATIONAL DU CANCER 15 FEB 2001 LNKD- PUBMED:11251980, vol. 91, no. 4, 15 February 2001 (2001-02-15), pages 550 - 554, XP002655272, ISSN: 0020-7136
  • [X] YAN Z ET AL: "N-glucuronidation of the platelet-derived growth factor receptor tyrosine kinase inhibitor 6,7-(dimethoxy-2,4-dihydroindeno[1,2-c]pyra zol-3-yl)-(3-fluoro-phenyl)-amine by human UDP-glucuronosyltransferases", DRUG METABOLISM AND DISPOSITION, vol. 34, no. 5, May 2006 (2006-05-01), pages 748 - 755, XP002655273, ISSN: 0090-9556
  • See references of WO 2007149827A2

Designated contracting state (EPC)

AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU LV MC MT NL PL PT RO SE SI SK TR

DOCDB simple family (publication)

WO 2007149827 A2 20071227; WO 2007149827 A3 20090423; EP 2037954 A2 20090325; EP 2037954 A4 20110914

DOCDB simple family (application)

US 2007071510 W 20070619; EP 07812192 A 20070619