Global Patent Index - EP 2044437 A4

EP 2044437 A4 20091125 - METHODS FOR DETECTING MOLECULAR COMPLEXES

Title (en)

METHODS FOR DETECTING MOLECULAR COMPLEXES

Title (de)

VERFAHREN FÜR DEN NACHWEIS MOLEKULARER KOMPLEXE

Title (fr)

PROCEDES DE DETECTION DE COMPLEXES MOLECULAIRES

Publication

EP 2044437 A4 20091125 (EN)

Application

EP 07798658 A 20070615

Priority

  • US 2007071382 W 20070615
  • US 81383806 P 20060615

Abstract (en)

[origin: WO2007147141A2] The invention includes methods for analyzing copies of an antibody microarray for a protein complexed with another molecule. In this method, one biological sample is divided and then incubated with copies of an antibody microarray. Each capture antibody is paired with a detection antibody, and only one detection antibody is incubated with each copy of the antibody microarray. The invention further includes methods to compare protein complexes under different conditions, methods of detecting an auto-immune response, and methods of detecting interaction between a protein and a small molecule.

IPC 8 full level

G01N 33/68 (2006.01); G01N 33/53 (2006.01)

CPC (source: EP)

G01N 33/543 (2013.01); G01N 33/54306 (2013.01); G01N 33/6842 (2013.01); G01N 33/6845 (2013.01)

Citation (search report)

  • [X] US 6197599 B1 20010306 - CHIN GUORONG [US], et al
  • [A] LIANG M ET AL: "Ubiquitination and proteolysis of cancer-derived Smad4 mutants by SCFSkp2.", MOL CELL BIOL, vol. 24, no. 17, September 2004 (2004-09-01), pages 7524 - 7537, XP002546377
  • [X] KATAGIRI C ET AL: "Serpin squamous cell carcinoma antigen inhibits UV-induced apoptosis via suppression of c-JUN NH2-terminal kinase.", J CELL BIOL, vol. 172, no. 7, 27 March 2006 (2006-03-27), pages 983 - 990, XP002546378
  • [A] KORF U ET AL: "Protein microarrays as a discovery tool for studying protein-protein interactions", EXPERT REV PROTEOMICS, vol. 2, no. 1, 1 January 2005 (2005-01-01), pages 13 - 26, XP009121228
  • [PX] BERGSMA D ET AL: "Antibody-array interaction mapping: a new method for studying protein-protein interactions and its application to the study of sera from pancreatic cancer patients.", PROC AM ASSOC CANCER RES ANN MEETING, vol. 48, April 2007 (2007-04-01), & 98TH ANN MEETING AM ASSOC CANCER RES; LOS ANGELES, CA, USA; 14-18.04.2007, pages 909, XP002546379
  • See references of WO 2007147141A2

Designated contracting state (EPC)

AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU LV MC MT NL PL PT RO SE SI SK TR

DOCDB simple family (publication)

WO 2007147141 A2 20071221; WO 2007147141 A3 20080207; AU 2007260649 A1 20071221; CA 2655563 A1 20071221; EP 2044437 A2 20090408; EP 2044437 A4 20091125

DOCDB simple family (application)

US 2007071382 W 20070615; AU 2007260649 A 20070615; CA 2655563 A 20070615; EP 07798658 A 20070615