EP 2046814 A2 20090415 - MINIMIZED SMALL PEPTIDES WITH HIGH AFFINITY FOR FACTOR VIII AND FACTOR VIII-LIKE PROTEINS
Title (en)
MINIMIZED SMALL PEPTIDES WITH HIGH AFFINITY FOR FACTOR VIII AND FACTOR VIII-LIKE PROTEINS
Title (de)
MINIMIERTE KLEINE PEPTIDE MIT HOHER AFFINITÄT FÜR FAKTOR VIII UND FAKTOR-VIII-ÄHNLICHE PROTEINE
Title (fr)
PETITS PEPTIDES MINIMISÉS PRÉSENTANT UNE FORTE AFFINITÉ AU FACTEUR VIII ET PROTÉINES SIMILAIRES AU FACTEUR VIII
Publication
Application
Priority
- EP 2007056699 W 20070703
- EP 06013852 A 20060704
- EP 07787022 A 20070703
Abstract (en)
[origin: EP1876183A1] The present invention relates to the composition of small molecules and their use in the field of protein isolation, purification, stabilizing and/or enhancing its activity. In particular, the present invention relates to the synthesis and optimization of compounds comprising small peptides and peptide derivatives with affinity to coagulation Factor VIII and/or Factor VIII-like polypeptides and/or domains thereof. These compounds are useful for labeling, detecting, identifying, isolating and preferably for purifying, stabilizing and enhancing the activity of Factor VIII, Factor VIII-like polypeptides or domains thereof from physiological and non-physiological solutions comprising same. Further, these compounds may be used as ligands, which bind Factor VIII, Factor VIII-like polypeptides or domains thereof in methods of the present invention.
IPC 8 full level
C07K 7/06 (2006.01); A61K 38/08 (2006.01); C07K 14/755 (2006.01); G01N 33/68 (2006.01)
CPC (source: EP US)
C07K 7/06 (2013.01 - EP US); C07K 14/755 (2013.01 - EP US)
Citation (search report)
See references of WO 2008003707A2
Designated contracting state (EPC)
AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU LV MC MT NL PL PT RO SE SI SK TR
Designated extension state (EPC)
AL BA HR MK RS
DOCDB simple family (publication)
EP 1876183 A1 20080109; EP 2046814 A2 20090415; US 2010099113 A1 20100422; WO 2008003707 A2 20080110; WO 2008003707 A3 20080410
DOCDB simple family (application)
EP 06013852 A 20060704; EP 07787022 A 20070703; EP 2007056699 W 20070703; US 30715807 A 20070703