Title (en)

MODULATORS OF UDP-GLUCOSE CERAMIDE GLUCOSYLTRANSFERASE IN THE TREATMENT OF ACNE OR OF HYPERKERATINIZATION

Title (de)

MODULATOREN VON UPD-GLUCOSE-CERAMID-GLUCOSYLTRANSFERASE BEI DER BEHANDLUNG VON AKNE ODER DER HYPERKERATINIZATION

Title (fr)

MODULATEURS DE LA UDP-GLUCOSE CÉRAMIDE GLUCOSYLTRANSFÉRASE DANS LE TRAITEMENT DE L'ACNÉ OU DE L'HYPERKÉRATINISATION

Publication

EP 2046978 A2 20090415 (FR)

Application

EP 07823603 A 20070718

Priority

• FR 2007051684 W 20070718
• FR 0653030 A 20060719

Abstract (en)

[origin: WO2008009857A2] The invention relates to an in vitro method of screening for candidate compounds for the preventive or curative treatment of acne, comprising the determination of the ability of a compound to modulate the expression or the activity of UDP-glucose ceramide glucosyltransferase (UGCG), and also to the use of modulators of the expression or of the activity of this enzyme for the treatment of acne or of skin disorders associated with hyperkeratinization. The invention also relates to methods for the diagnosis or prognosis, in vitro, of these pathologies.

IPC 8 full level

C12Q 1/48 (2006.01)

CPC (source: EP US)

A61P 17/10 (2017.12 - EP); A61P 17/12 (2017.12 - EP); C12Q 1/48 (2013.01 - EP US); G01N 33/5008 (2013.01 - EP US); G01N 33/6893 (2013.01 - EP US); G01N 2333/91102 (2013.01 - EP US); G01N 2500/00 (2013.01 - EP US); G01N 2800/20 (2013.01 - EP US)

Citation (search report)

See references of WO 2008009857A2

Designated contracting state (EPC)

AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU LV MC MT NL PL PT RO SE SI SK TR

Designated extension state (EPC)

AL BA HR MK RS

DOCDB simple family (publication)

WO 2008009857 A2 20080124; WO 2008009857 A3 20080424; CA 2656842 A1 20080124; EP 2046978 A2 20090415; FR 2904001 A1 20080125; US 2010028878 A1 20100204

DOCDB simple family (application)

FR 2007051684 W 20070718; CA 2656842 A 20070718; EP 07823603 A 20070718; FR 0653030 A 20060719; US 32016809 A 20090121