EP 2049085 A1 20090422 - MICROPARTICLES BASED ON AN AMPHIPHILIC COPOLYMER AND ON ACTIVE INGREDIENT(S) WITH MODIFIED RELEASE AND PHARMACEUTICAL FORMULATIONS CONTAINING SAME
Title (en)
MICROPARTICLES BASED ON AN AMPHIPHILIC COPOLYMER AND ON ACTIVE INGREDIENT(S) WITH MODIFIED RELEASE AND PHARMACEUTICAL FORMULATIONS CONTAINING SAME
Title (de)
MIKROTEILCHEN AUF BASIS EINES AMPHIPHILEN COPOLYMERS UND VON WIRKSTOFF(EN) MIT MODIFIZIERTER FREISETZUNG UND DIESE ENTHALTENDE PHARMAZEUTISCHE FORMULIERUNGEN
Title (fr)
MICROPARTICULES A BASE DE COPOLYMERE AMPHIPHILE ET DE PRINCIPE(S) ACTIF(S) A LIBERATION MODIFIEE ET FORMULATIONS PHARMACEUTIQUES EN CONTENANT
Publication
Application
Priority
- EP 2007006722 W 20070730
- FR 0653191 A 20060728
Abstract (en)
[origin: FR2904219A1] Polymeric microparticle (I) comprising an active ingredient is claimed. The polymer present in (I) is amphiphilic, biodegradable, hydro-soluble copolymer with hydrophobic and hydrophilic groups, spontaneously forms a colloidal suspension of nanoparticles in water at a pH of 7 under isotonic condition. (I) is non-covalently bonded to the active ingredient and obtained by atomization of a solution or a colloidal suspension of (I), has a size of 0.5-100 mu m, preferably 2-40 mu m and is dispersible in colloidal suspension measured by a dispersibility test described in the given specification. Independent claims are included for: (1) a process of preparing (I) comprising atomizing a solution or a colloidal suspension of (I); (2) a liquid/solid pharmaceutical formulation for the sustained release of the active ingredient comprising a less viscous colloidal suspension; (3) requirements for a reconstitution process comprising (I) and a reconstituting liquid like an aqueous liquid, water (non)miscible organic liquid; and (4) a reconstitution process comprising mixing and agitating the given requirements.
IPC 8 full level
A61K 9/16 (2006.01); A61K 9/10 (2006.01); A61K 9/12 (2006.01); A61K 38/00 (2006.01); C08G 69/10 (2006.01); C08G 69/48 (2006.01)
CPC (source: EP KR)
A61K 9/10 (2013.01 - EP KR); A61K 9/16 (2013.01 - KR); A61K 9/1641 (2013.01 - EP); A61K 38/16 (2013.01 - KR); A61P 11/00 (2017.12 - EP); A61K 9/0019 (2013.01 - EP); A61K 9/0073 (2013.01 - EP)
Citation (search report)
See references of WO 2008025425A1
Designated contracting state (EPC)
AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU LV MC MT NL PL PT RO SE SI SK TR
Designated extension state (EPC)
AL BA HR MK RS
DOCDB simple family (publication)
FR 2904219 A1 20080201; FR 2904219 B1 20100813; AU 2007291577 A1 20080306; BR PI0714943 A2 20130521; CA 2661567 A1 20080306; CA 2661567 C 20160920; CN 101568328 A 20091028; CN 101568328 B 20120905; EP 2049085 A1 20090422; IL 196426 A0 20090922; IL 196426 A 20140731; JP 2009544759 A 20091217; JP 5302197 B2 20131002; KR 101407033 B1 20140620; KR 20090054976 A 20090601; MX 2009000951 A 20090204; WO 2008025425 A1 20080306; WO 2008025425 A8 20090416; WO 2008025425 A9 20080612; WO 2008025425 B1 20080502; ZA 200900929 B 20100630
DOCDB simple family (application)
FR 0653191 A 20060728; AU 2007291577 A 20070730; BR PI0714943 A 20070730; CA 2661567 A 20070730; CN 200780031893 A 20070730; EP 07801468 A 20070730; EP 2007006722 W 20070730; IL 19642609 A 20090111; JP 2009525938 A 20070730; KR 20097004345 A 20070730; MX 2009000951 A 20070730; ZA 200900929 A 20070730