EP 2057149 B1 20141029 - PSEUDOBASE BENZO [C]PHENANTHRIDINES WITH IMPROVED EFFICACY, STABILITY, AND SAFETY
Title (en)
PSEUDOBASE BENZO [C]PHENANTHRIDINES WITH IMPROVED EFFICACY, STABILITY, AND SAFETY
Title (de)
PSEUDOBASISCHE BENZO-[C]-PHENANTHRIDINE MIT ERHÖHTER EFFIZIENZ, STABILITÄT UND SICHERHEIT
Title (fr)
BENZO[C]PHÉNANTHRIDINES PSEUDO-BASIQUES PRÉSENTANT UNE EFFICACITÉ, UNE STABILITÉ ET UNE INNOCUITÉ AMÉLIORÉES
Publication
Application
Priority
- US 2007017095 W 20070731
- US 83437506 P 20060731
Abstract (en)
[origin: WO2008016596A2] Pseudobase benzo[c]?henanthridines and the pharmaceutically acceptable salts thereof of Formula I (i) are provided herein. The variables R, Rj, R2, R3, and R4 are defined herein. Certain pseudobase benzo[c]phenanthridines provided herein act as prodrugs, targeting the parent benzo[c]phenanthridinium alkaloid to hydrophilic or hydrophobic regions in the body. Pharmaceutical compositions comprising a pseudobase benzo[c]phenanthridine and a carrier, excipient, or diluent are provided herein. Methods of treating or preventing microbial, fungal and or viral infections and methods of treating diseases and disorders responsive to protein kinase C modulation, topoisomerase I, and/or topoisomerase II modulation are also provided.
IPC 8 full level
A61K 31/357 (2006.01); C07D 317/70 (2006.01); C07D 405/12 (2006.01)
CPC (source: EP US)
A61P 25/00 (2017.12 - EP); A61P 25/18 (2017.12 - EP); A61P 29/00 (2017.12 - EP); A61P 31/04 (2017.12 - EP); A61P 31/10 (2017.12 - EP); A61P 31/12 (2017.12 - EP); A61P 31/18 (2017.12 - EP); A61P 35/00 (2017.12 - EP); A61P 43/00 (2017.12 - EP); C07D 491/04 (2013.01 - EP US)
Designated contracting state (EPC)
AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU LV MC MT NL PL PT RO SE SI SK TR
DOCDB simple family (publication)
WO 2008016596 A2 20080207; WO 2008016596 A3 20080410; EP 2057149 A2 20090513; EP 2057149 B1 20141029; ES 2528796 T3 20150212; JP 2009545594 A 20091224; US 2008076781 A1 20080327; US 2008096566 A1 20080424; US 7531550 B2 20090512; US 8045996 B2 20111025
DOCDB simple family (application)
US 2007017095 W 20070731; EP 07810944 A 20070731; ES 07810944 T 20070731; JP 2009522837 A 20070731; US 83065707 A 20070730; US 83149807 A 20070731