EP 2057190 A2 20090513 - ANTI-INTERFERON ALPHA MONOCLONAL ANTIBODIES AND METHODS FOR USE
Title (en)
ANTI-INTERFERON ALPHA MONOCLONAL ANTIBODIES AND METHODS FOR USE
Title (de)
MONOKLONALE ANTI-INTERFERON-ALPHA-ANTIKÖRPER UND VERWENDUNGSVERFAHREN DAFÜR
Title (fr)
ANTICORPS MONOCLONAUX ANTI-INTERFÉRON ALPHA ET LEURS PROCÉDÉS D'UTILISATION
Publication
Application
Priority
- US 2007075616 W 20070809
- US 83659906 P 20060809
Abstract (en)
[origin: WO2008021976A2] The present invention includes compositions and methods that include antibodies that selectively neutralize a bioactivity of at least two interferon alpha ("IFNa") protein subtypes for the protein subtypes A, 2, B2, C, F, G, H2, 1, J1, K, 4a, 4b and WA, but does not neutralize at least one bioactivity of IFNa protein subtype D. Examples of bioactivity for measurement include activation of the MxA promoter or antiviral activity and variants, derivatives and fragments thereof. The invention also includes host cells, hybridomas and plasmacytomas that produce antibodies. Because of their unique selectivity and affinity, the antibodies of the present invention are useful to detect IFNa subtypes in sample or tissue and/or for therapeutic applications that include, but are not limited to the treatment and/or amelioration of an IFNa related disorder such as SLE, lupus, type 1 diabetes, psoriasis, AIDS and Graft versus Host Disease.
IPC 8 full level
C07K 16/24 (2006.01); A61K 39/395 (2006.01)
CPC (source: EP)
A61P 3/10 (2017.12); A61P 17/02 (2017.12); A61P 17/06 (2017.12); A61P 29/00 (2017.12); A61P 31/12 (2017.12); A61P 31/18 (2017.12); A61P 37/06 (2017.12); A61P 43/00 (2017.12); C07K 16/249 (2013.01); A61K 2039/505 (2013.01); C07K 2317/24 (2013.01); C07K 2317/56 (2013.01); C07K 2317/565 (2013.01); C07K 2317/76 (2013.01)
Designated contracting state (EPC)
AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU LV MC MT NL PL PT RO SE SI SK TR
Designated extension state (EPC)
AL BA HR MK RS
DOCDB simple family (publication)
WO 2008021976 A2 20080221; WO 2008021976 A3 20081113; EP 2057190 A2 20090513; EP 2057190 A4 20100728; JP 2010500380 A 20100107; JP 5230022 B2 20130710
DOCDB simple family (application)
US 2007075616 W 20070809; EP 07840833 A 20070809; JP 2009524004 A 20070809