Global Patent Index - EP 2057278 A2

EP 2057278 A2 20090513 - METHOD FOR IDENTIFYING PROTEASE INHIBITORS

Title (en)

METHOD FOR IDENTIFYING PROTEASE INHIBITORS

Title (de)

VERFAHREN ZUR IDENTIFIKATION VON PROTEASE-HEMMERN

Title (fr)

PROCÉDÉ POUR IDENTIFIER DES INHIBITEURS DE PROTÉASES

Publication

EP 2057278 A2 20090513 (EN)

Application

EP 07811572 A 20070828

Priority

  • US 2007018945 W 20070828
  • US 84057306 P 20060828

Abstract (en)

[origin: WO2008027397A2] The invention describes a method for assaying HCV NS3 protease activity using an NS3·4A protease molecule. The invention also provides a method for screening and identifying modulators of NS3 protease.

IPC 8 full level

C12Q 1/37 (2006.01); C12Q 1/70 (2006.01)

CPC (source: EP)

C12Q 1/37 (2013.01)

Citation (search report)

See references of WO 2008027397A2

Citation (examination)

  • ZHANG RUMIN ET AL: "A continuous spectrophotometric assay for the hepatitis C virus serine protease", ANALYTICAL BIOCHEMISTRY, vol. 270, no. 2, 1 June 1999 (1999-06-01), pages 268 - 275, ISSN: 0003-2697
  • YASUAKI SHIMIZU ET AL: "IDENRIFICATION OF THE SEQUENCE ON NS4A REQUIRED FOR ENHANCED CLEAVAGE OF THE NS5A/5B SITE BY HEPATITIS C VIRUS NS3 PROTEASE", JOURNAL OF VIROLOGY, THE AMERICAN SOCIETY FOR MICROBIOLOGY, US, vol. 70, no. 1, 1 January 1996 (1996-01-01), pages 127 - 132, XP000577885, ISSN: 0022-538X
  • SUDO K ET AL: "ESTABLISHMENT OF AN IN VITRO ASSAY SYSTEM FOR SCREENING HEPATITIS CVIRUS PROTEASE INHIBITORS USING HIGH PERFORMANCE LIQUID CHROMATOGRAPHY", ANTIVIRAL RESEARCH, ELSEVIER BV, NL, vol. 32, no. 1, 1 January 1996 (1996-01-01), pages 9 - 18, XP000608038, ISSN: 0166-3542, DOI: 10.1016/0166-3542(95)00969-8
  • LIN CHAO ET AL: "The hepatitis C virus NS3 serine proteinase and NS4A cofactor: Establishment of a cell-free trans-processing assay", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF USA, NATIONAL ACADEMY OF SCIENCE, WASHINGTON, DC; US, vol. 92, no. 17, 1 January 1995 (1995-01-01), pages 7622 - 7626, XP002158507, ISSN: 0027-8424, DOI: 10.1073/PNAS.92.17.7622
  • ARCHER SHARON J ET AL: "Hepatitis C virus NS3 protease requires its NS4A cofactor peptide for optimal binding of a boronic acid inhibitor as shown by NMR", CHEMISTRY AND BIOLOGY (LONDON), vol. 9, no. 1, January 2002 (2002-01-01), pages 79 - 92, ISSN: 1074-5521
  • LANDRO E A: "Mechanistic role of NS4A peptide cofactor with the truncated NS3 protease of HCV: elucidation of the NS4A stimulatory efect via kinetic mapping and inhibitor mapping", BIOCHEMISTRY, AMERICAN CHEMICAL SOCIETY, US, vol. 36, 5 August 1997 (1997-08-05), pages 9340 - 9348, XP002086573, ISSN: 0006-2960, DOI: 10.1021/BI963054N
  • ZHOU YI ET AL: "Phenotypic and structural analyses of hepatitis C virus NS3 protease Arg(155) variants - Sensitivity to telaprevir (VX-950) and interferon alpha", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 282, no. 31, August 2007 (2007-08-01), pages 22619 - 22628, XP055026781, ISSN: 0021-9258, DOI: doi:10.1074/jbc.M610207200

Designated contracting state (EPC)

AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU LV MC MT NL PL PT RO SE SI SK TR

Designated extension state (EPC)

AL BA HR MK RS

DOCDB simple family (publication)

WO 2008027397 A2 20080306; WO 2008027397 A3 20080522; AU 2007290535 A1 20080306; EP 2057278 A2 20090513; JP 2010502184 A 20100128; NZ 575186 A 20120330

DOCDB simple family (application)

US 2007018945 W 20070828; AU 2007290535 A 20070828; EP 07811572 A 20070828; JP 2009526684 A 20070828; NZ 57518607 A 20070828