Global Patent Index - EP 2060261 A1

EP 2060261 A1 20090520 - C-19 steroids for cosmetic uses

Title (en)

C-19 steroids for cosmetic uses

Title (de)

C-19-Steroide zur kosmetischen Verwendung

Title (fr)

Stéroïdes C-19 pour des utilisations cosmétiques

Publication

EP 2060261 A1 20090520 (EN)

Application

EP 07022015 A 20071113

Priority

EP 07022015 A 20071113

Abstract (en)

The present invention relates to novel uses of C-19 steroid compounds, in particular C-19 steroids having an androsten-17-(OR 4 )-3-one structure for cosmetic and further uses, wherein R 4 is hydrogen or an unsubstituted or substituted alkyl, aryl, acyl or any group leading to hydroxyl upon biological metabolization or chemical deprotection. The present invention particularly relates to selected C-19 steroids displaying properties of high binding affinity to androgen receptor to block dihydotestosterone from binding, while at the same time providing anabolic effects, which is useful for certain applications, particularly for influencing or controlling problems of the skin and its skin-associated body structures like cellulite, wrinkles, adipose fat tissues, hair follikles or hair growth; for influencing or controlling gland function and activity such as the sebaceous gland and other glands affecting the skin and/or perspiration. The present invention also describes a composition comprising a combination of such a compound and dimethyl isosorbide.

IPC 8 full level

A61K 31/568 (2006.01); A61K 8/63 (2006.01); A61K 9/16 (2006.01); A61K 9/20 (2006.01); A61Q 7/00 (2006.01); A61Q 7/02 (2006.01); A61Q 15/00 (2006.01); A61Q 19/06 (2006.01); A61Q 19/08 (2006.01)

CPC (source: EP US)

A61K 8/63 (2013.01 - EP US); A61K 31/568 (2013.01 - EP US); A61P 17/00 (2017.12 - EP); A61P 17/02 (2017.12 - EP); A61P 17/14 (2017.12 - EP); A61Q 7/00 (2013.01 - EP US); A61Q 7/02 (2013.01 - EP US); A61Q 15/00 (2013.01 - EP US); A61Q 19/06 (2013.01 - EP US); A61Q 19/08 (2013.01 - EP US); A61K 9/1623 (2013.01 - EP US); A61K 9/2018 (2013.01 - EP US)

Citation (applicant)

  • US 2762818 A 19560911 - HAROLD LEVY, et al
  • US 2003229063 A1 20031211 - LLEWELLYN WILLIAM CHARLES [US]
  • WO 2005062760 A2 20050714 - UNIV ROCHESTER [US], et al
  • US 2003199487 A1 20031023 - ABRAHAM SAL [US]
  • MITAMURA ET AL., ANALYTICAL SCIENCES, vol. 21, 2005, pages 1241 - 1244
  • RAYNAUD ET AL., J. STEROID BIOCHEM., vol. 6, 1975, pages 615 - 622
  • ITAMI; INUI, J. INVESTIG. DERMATOL. SYMP. BROK., vol. 10, no. 3, 2005, pages 209 - 211
  • ANDO ET AL., BR J DERMATOL., vol. 141, no. 5, 1999, pages 840 - 845
  • ITAMI ET AL., J DERMATOL SCI., vol. 7, 1994, pages 98 - 103
  • LIANG ET AL., J. INVEST. DERMATOL., vol. 100, no. 5, 1993, pages 663 - 666
  • MEIER ET AL., J. CLIN. ENDOCRINOL. METAB., vol. 89, no. 6, 2004, pages 2033 - 241
  • VIENNET ET AL., ARCH DERMATOL RES., vol. 297, no. 1, 2005, pages 10 - 17
  • BEIER ET AL., HISTOCHEM CELL BIO1, vol. 123, no. 1, 2005, pages 61 - 65
  • LABRIE ET AL., HORM RES., vol. 54, no. 5-6, 2000, pages 218 - 229
  • IMPERATO-MCGINLEY ET AL., J CLIN ENDOCRINOL METAB., vol. 76, no. 2, 1993, pages 524 - 528
  • AKAMATSU ET AL., J INVEST DERMATOL., vol. 99, no. 4, 1992, pages 509 - 511
  • KURATA ET AL., J DERMATOL SCI., vol. 2, no. 2, 1991, pages 75 - 78

Citation (search report)

Designated contracting state (EPC)

AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU LV MC MT NL PL PT RO SE SI SK TR

Designated extension state (EPC)

AL BA HR MK RS

DOCDB simple family (publication)

EP 2060261 A1 20090520; EP 2060261 B1 20160309; AU 2008323198 A1 20090522; AU 2008323198 B2 20140320; CA 2705529 A1 20090522; CA 2705529 C 20161011; CN 101854908 A 20101006; CN 101854908 B 20130306; DK 2060261 T3 20160613; EP 2207523 A1 20100721; ES 2574933 T3 20160623; HK 1148669 A1 20110916; JP 2011503129 A 20110127; KR 101776544 B1 20170907; KR 20100087005 A 20100802; KR 20160036098 A 20160401; US 2010256102 A1 20101007; US 8258123 B2 20120904; WO 2009062682 A1 20090522

DOCDB simple family (application)

EP 07022015 A 20071113; AU 2008323198 A 20081112; CA 2705529 A 20081112; CN 200880115838 A 20081112; DK 07022015 T 20071113; EP 08850748 A 20081112; EP 2008009540 W 20081112; ES 07022015 T 20071113; HK 11102719 A 20110318; JP 2010533486 A 20081112; KR 20107010502 A 20081112; KR 20167007415 A 20081112; US 73462108 A 20081112