Global Patent Index - EP 2064183 A2

EP 2064183 A2 20090603 - HETEROAROMATIC COMPOUNDS HAVING SPHINGOSINE-1-PHOSPHATE (S1P) RECEPTOR AGONIST BIOLOGICAL ACTIVITY

Title (en)

HETEROAROMATIC COMPOUNDS HAVING SPHINGOSINE-1-PHOSPHATE (S1P) RECEPTOR AGONIST BIOLOGICAL ACTIVITY

Title (de)

HETEROAROMATISCHE VERBINDUNGEN MIT BIOLOGISCHER SPHINGOSIN-1-PHOSPHAT-REZEPTORAGONISTEN-AKTIVITÄT

Title (fr)

COMPOSÉS HÉTÉROAROMATIQUES AYANT UNE ACTIVITÉ BIOLOGIQUE D'AGONISTE DE RÉCEPTEUR DE SPHINGOSINE-1-PHOSPHATE (S1P)

Publication

EP 2064183 A2 20090603 (EN)

Application

EP 07841847 A 20070905

Priority

  • US 2007077581 W 20070905
  • US 82480506 P 20060907

Abstract (en)

[origin: WO2008030838A2] A novel compound having agonist activity at the S<SUB>1</SUB>P<SUB>3</SUB> receptor which is represented by the formula (I) wherein X is selected from the group consisting of CR<SUP>3</SUP>, N and NO; Y is selected from the group consisting of CR<SUP>3</SUP>, N and NO; Z is selected from the group consisting of CR<SUP>3</SUP>, N and NO; and at least one of X, Y and Z is N or NO; V is O or NOR<SUP>4</SUP> R<SUP>1</SUP> is an aryl group; R<SUP>2</SUP> is an aryl group; R<SUP>3</SUP> is selected from the group consisting of H and alkyl; and 2 of said R<SUP>3</SUP> groups may together form a cyclic alkyl ring having from 3 to 6 carbon atoms; R<SUP>4</SUP> is selected from the group consisting of H and alkyl; a is 0 or an integer of from 1 to 6; b is 0 or 1; c is 0 or 1; f is 0 or an integer of 1 or 2; x is 0 or 1; y is 0 or an integer of from 1 to 3; and z is 0 or an integer of from 1 to 3.

IPC 8 full level

C07D 213/30 (2006.01); C07D 213/79 (2006.01)

CPC (source: EP)

A61P 31/10 (2018.01); A61P 37/02 (2018.01); A61P 37/08 (2018.01); A61P 43/00 (2018.01); C07D 213/30 (2013.01); C07D 213/50 (2013.01); C07D 213/53 (2013.01); C07D 213/74 (2013.01); C07D 213/79 (2013.01); C07D 213/89 (2013.01); C07D 239/28 (2013.01); C07D 241/12 (2013.01); C07D 241/24 (2013.01); C07D 253/07 (2013.01)

Citation (search report)

See references of WO 2008030838A3

Designated contracting state (EPC)

AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU LV MC MT NL PL PT RO SE SI SK TR

Designated extension state (EPC)

AL BA HR MK RS

DOCDB simple family (publication)

WO 2008030838 A2 20080313; WO 2008030838 A3 20081127; AU 2007292436 A1 20080313; BR PI0716601 A2 20130917; CA 2662850 A1 20080313; EP 2064183 A2 20090603; JP 2010502728 A 20100128

DOCDB simple family (application)

US 2007077581 W 20070905; AU 2007292436 A 20070905; BR PI0716601 A 20070905; CA 2662850 A 20070905; EP 07841847 A 20070905; JP 2009527529 A 20070905