EP 2064217 A2 20090603 - AN IMPROVED PROCESS FOR THE PREPARATION OF CLOPIDOGREL AND ITS PHARMACEUTICALLY ACCEPTABLE SALTS
Title (en)
AN IMPROVED PROCESS FOR THE PREPARATION OF CLOPIDOGREL AND ITS PHARMACEUTICALLY ACCEPTABLE SALTS
Title (de)
VERBESSERTES VERFAHREN ZUR HERSTELLUNG VON CLOPIDOGREL UND PHARMAZEUTISCH UNBEDENKLICHEN SALZEN DAVON
Title (fr)
PROCÉDÉ AMÉLIORÉ DE PRÉPARATION DE CLOPIDOGREL ET SES SELS PHARMACEUTIQUEMENT ACCEPTABLES
Publication
Application
Priority
- IB 2007053562 W 20070904
- IN 1971DE2006 A 20060904
Abstract (en)
[origin: US8247558B2] The present invention provides a process for the preparation of clopidogrel and its pharmaceutically acceptable salts thereof comprises the resolving racemic methyl alpha-5-(4,5,6,7-tetrahydro[3,2-c]thienopyridyl)(2-chlorophenyl)-acetate by the salt formation of methyl alpha-5-(4,5,6,7-tetrahydro[3,2-c]thienopyridyl)(2-chlorophenyl)-acetate with excess levorotatory camphor-10-sulfonic acid to get a maximum yield of camphor sulphonate salt of methyl S-(+)-alpha-5-(4,5,6,7-tetrahydro[3,2-c]thienopyridyl) (2-chlorophenyl)-acetate and transforming the camphor sulphonate salt to clopidogrel or its pharmaceutically acceptable salts thereof.
IPC 8 full level
C07D 495/04 (2006.01)
CPC (source: EP US)
C07D 495/04 (2013.01 - EP US)
Designated contracting state (EPC)
AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU LV MC MT NL PL PT RO SE SI SK TR
Designated extension state (EPC)
AL BA HR MK RS
DOCDB simple family (publication)
WO 2008029350 A2 20080313; WO 2008029350 A3 20080515; WO 2008029350 B1 20080724; AT E496055 T1 20110215; DE 602007012121 D1 20110303; DK 2064217 T3 20110509; EP 2064217 A2 20090603; EP 2064217 B1 20110119; ES 2359851 T3 20110527; PT 2064217 E 20110419; US 2010016594 A1 20100121; US 8247558 B2 20120821
DOCDB simple family (application)
IB 2007053562 W 20070904; AT 07826258 T 20070904; DE 602007012121 T 20070904; DK 07826258 T 20070904; EP 07826258 A 20070904; ES 07826258 T 20070904; PT 07826258 T 20070904; US 43964207 A 20070904