EP 2064318 A1 20090603 - A METHOD FOR PRODUCING LANGERHANS CELLS AND/OR DERMAL/INTERSTITIAL DENTRITIC CELLS FROM CD14+ MONOCYTES
Title (en)
A METHOD FOR PRODUCING LANGERHANS CELLS AND/OR DERMAL/INTERSTITIAL DENTRITIC CELLS FROM CD14+ MONOCYTES
Title (de)
VERFAHREN ZUR HERSTELLUNG VON LANGERHANSSCHEN ZELLEN UND/ODER DERMALEN/INTERSTITIELLEN DENDRITISCHEN ZELLEN AUS CD14+-MONOZYTEN
Title (fr)
PROCÉDÉ DE PRODUCTION DE CELLULES DE LANGERHANS ET/OU DES CELLULES DENDRITIQUES DERMIQUES/INTERSTITIELLES À PARTIR DE MONOCYTES CD14+
Publication
Application
Priority
- EP 2007059165 W 20070903
- FR 0653567 A 20060904
Abstract (en)
[origin: CA2662231A1] The present invention relates to a method for preparing Langerhans cells (LC), or dermal/interstitial dendritic cells (IDC) or LCs and IDCs from CD 1 4+ monocytes stemming from peripheral circulatory blood of a living being, a nd notably of a human being, comprising differentiation of CD 14+ monocytes into LCs, or into IDCs, or into LCs and IDCs by putting the CD 14+ monocytes in the presence of a cell environment comprising epithelial cells, such as keratinocytes, and/or mesenchymatous cells such as dermal fibroblasts. The p resent invention also relates to cell or tissue models comprising at least L Cs and/or IDCs, and optionally macrophages and endothelial cells, able to be obtained according to this method, and to their uses.
IPC 8 full level
C12N 5/071 (2010.01); C12N 5/0784 (2010.01)
CPC (source: EP KR)
A61P 17/16 (2018.01 - EP); A61P 37/02 (2018.01 - EP); C12N 5/00 (2013.01 - KR); C12N 5/0634 (2013.01 - EP KR); C12N 5/0639 (2013.01 - EP KR); C12N 5/0697 (2013.01 - EP); C12N 5/0698 (2013.01 - EP); C12N 2502/094 (2013.01 - EP); C12N 2502/097 (2013.01 - EP); C12N 2502/1121 (2013.01 - EP); C12N 2502/1157 (2013.01 - EP); C12N 2502/1323 (2013.01 - EP); C12N 2502/243 (2013.01 - EP)
Designated contracting state (EPC)
AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU LV MC MT NL PL PT RO SE SI SK TR
Designated extension state (EPC)
AL BA HR MK RS
DOCDB simple family (publication)
FR 2905380 A1 20080307; FR 2905380 B1 20081205; BR PI0716107 A2 20130924; CA 2662231 A1 20080313; EP 2064318 A1 20090603; JP 2010502175 A 20100128; KR 20090049620 A 20090518; WO 2008028882 A1 20080313
DOCDB simple family (application)
FR 0653567 A 20060904; BR PI0716107 A 20070903; CA 2662231 A 20070903; EP 07803152 A 20070903; EP 2007059165 W 20070903; JP 2009526123 A 20070903; KR 20097006847 A 20090403