Global Patent Index - EP 2065395 A1

EP 2065395 A1 20090603 - Gene expression associated with osteoblast differentiation

Title (en)

Gene expression associated with osteoblast differentiation

Title (de)

Genexpression, die mit Osteoblastendifferenzierung assoziiert ist

Title (fr)

Expression génétique associée avec la différenciation des ostéoblastes

Publication

EP 2065395 A1 20090603 (EN)

Application

EP 09151973 A 20040405

Priority

  • EP 07119293 A 20040405
  • EP 04725691 A 20040405
  • US 46283403 P 20030414

Abstract (en)

The present invention identifies genes whose expression pattern is altered when pre-osteoblastic cells undergo differentiation into mature osteoblasts. The genes identified may be used as markers for the differentiation process. The present invention also provides methods to screen agents that are capable of modulating the differentiation process. The present invention also provides methods of identifying therapeutic agents that stimulate bone formation by analyzing the expression of one or more of the genes identified.

IPC 8 full level

C07K 14/47 (2006.01); C12Q 1/68 (2006.01)

CPC (source: EP US)

C12Q 1/6813 (2013.01 - EP US); C12Q 1/6883 (2013.01 - EP US); C12Q 2600/136 (2013.01 - EP US); C12Q 2600/158 (2013.01 - EP US)

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Citation (search report)

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  • [Y] WO 0119855 A2 20010322 - AMERICAN HOME PROD [US], et al
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Designated contracting state (EPC)

AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IT LI LU MC NL PL PT RO SE SI SK TR

DOCDB simple family (publication)

WO 2004090161 A1 20041021; EP 1616026 A1 20060118; EP 2065395 A1 20090603; JP 2006523444 A 20061019; US 2007105101 A1 20070510; US 2008118521 A1 20080522

DOCDB simple family (application)

EP 2004003588 W 20040405; EP 04725691 A 20040405; EP 09151973 A 20040405; JP 2006504999 A 20040405; US 55231904 A 20040405; US 92436707 A 20071025