Global Patent Index - EP 2069297 A1

EP 2069297 A1 20090617 - 2-METHYLENE-(20R,25S)-19,27-DINOR-(22E)-VITAMIN D ANALOGS

Title (en)

2-METHYLENE-(20R,25S)-19,27-DINOR-(22E)-VITAMIN D ANALOGS

Title (de)

2-METHYLEN-(20R,25S)-19,27-DINOR-(22E)-VITAMIN-D-ANALOGA

Title (fr)

ANALOGUES DE 2-MÉTHYLÈNE-(20R,25S)-19,27-DINOR-(22E)-VITAMINE D

Publication

EP 2069297 A1 20090617 (EN)

Application

EP 07843120 A 20070925

Priority

  • US 2007079384 W 20070925
  • US 84880306 P 20060928

Abstract (en)

[origin: WO2008039754A1] This invention discloses 2-methylene-(20R,25S)-19,27-dinor-(22E)-vitamin D analogs, and specifically 2-methylene-(20R,25S)-19,27-dinor-(22E)-la,25-dihydroxyvitamin D3, and pharmaceutical uses therefor. This compound exhibits pronounced activity in arresting the proliferation of undifferentiated cells and inducing their differentiation to the monocyte thus evidencing use as an anti-cancer agent and for the treatment of skin diseases such as psoriasis as well as skin conditions such as wrinkles, slack skin, dry skin and insufficient sebum secretion. This compound also has little, if any, calcemic activity and therefore may be used to treat autoimmune disorders or inflammatory diseases in humans as well as renal osteodystrophy. This compound may also be used for the treatment or prevention of obesity.

IPC 8 full level

C07C 401/00 (2006.01); A61K 31/59 (2006.01); A61P 3/04 (2006.01); A61P 17/06 (2006.01); A61P 35/00 (2006.01)

CPC (source: EP)

A61P 1/04 (2018.01); A61P 3/04 (2018.01); A61P 3/10 (2018.01); A61P 11/06 (2018.01); A61P 17/00 (2018.01); A61P 17/06 (2018.01); A61P 19/00 (2018.01); A61P 19/02 (2018.01); A61P 25/00 (2018.01); A61P 29/00 (2018.01); A61P 35/00 (2018.01); A61P 35/02 (2018.01); A61P 37/00 (2018.01); A61P 37/02 (2018.01); A61P 37/06 (2018.01); A61P 43/00 (2018.01); C07C 401/00 (2013.01); Y02P 20/55 (2015.11)

Citation (search report)

See references of WO 2008039754A1

Designated contracting state (EPC)

AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU LV MC MT NL PL PT RO SE SI SK TR

Designated extension state (EPC)

AL BA HR MK RS

DOCDB simple family (publication)

WO 2008039754 A1 20080403; AU 2007300214 A1 20080403; CA 2662992 A1 20080403; EP 2069297 A1 20090617; JP 2010504995 A 20100218; MX 2009003241 A 20090505; NZ 575111 A 20120224; US 2008081800 A1 20080403; US 7741314 B2 20100622

DOCDB simple family (application)

US 2007079384 W 20070925; AU 2007300214 A 20070925; CA 2662992 A 20070925; EP 07843120 A 20070925; JP 2009530554 A 20070925; MX 2009003241 A 20070925; NZ 57511107 A 20070925; US 86087007 A 20070925