EP 2078197 A4 20100324 - HAPTENS, HAPTEN CONJUGATES, COMPOSITIONS THEREOF AND METHOD FOR THEIR PREPARATION AND USE
Title (en)
HAPTENS, HAPTEN CONJUGATES, COMPOSITIONS THEREOF AND METHOD FOR THEIR PREPARATION AND USE
Title (de)
HAPTENE, HAPTENKONJUGATE, ZUSAMMENSETZUNGEN DARAUS UND VERFAHREN FÜR IHRE HERSTELLUNG UND VERWENDUNG
Title (fr)
HAPTÈNES, CONJUGUÉS DE HAPTÈNE, COMPOSITIONS DE HAPTÈNE, PROCÉDÉ DE FABRICATION ET UTILISATION
Publication
Application
Priority
- US 2007023140 W 20071101
- US 85613306 P 20061101
Abstract (en)
[origin: WO2008063378A2] A method for performing a multiplexed diagnostic assay, such as for two or more different targets in a sample, is described. One embodiment comprised contacting the sample with two or more specific binding moieties that bind specifically to two or more different targets. The two or more specific binding moieties are conjugated to different haptens, and at least one of the haptens is an oxazole, a pyrazole, a thiazole, a nitroaryl compound other than dinitrophenyl, a benzofurazan, a triterpene, a urea, a thiourea, a rotenoid, a coumarin, a cyclolignan, a heterobiaryl, an azo aryl, or a benzodiazepine. The sample is contacted with two or more different anti-hapten antibodies that can be detected separately. The two or more different anti-hapten antibodies may be conjugated to different detectable labels.
IPC 8 full level
G01N 33/53 (2006.01); C07K 1/10 (2006.01); C07K 1/13 (2006.01); C12Q 1/68 (2006.01); G01N 33/532 (2006.01); G01N 33/533 (2006.01); G01N 33/535 (2006.01); G01N 33/58 (2006.01)
CPC (source: EP US)
A61P 35/00 (2017.12 - EP); A61P 37/04 (2017.12 - EP); C07D 215/52 (2013.01 - EP US); C07D 231/16 (2013.01 - EP US); C07D 241/44 (2013.01 - EP US); C07D 243/12 (2013.01 - EP US); C07D 271/08 (2013.01 - EP US); C07D 271/12 (2013.01 - EP US); C07D 277/48 (2013.01 - EP US); C07D 277/76 (2013.01 - EP US); C07D 311/12 (2013.01 - EP US); C07D 417/12 (2013.01 - EP US); C07D 491/052 (2013.01 - EP US); C07D 491/056 (2013.01 - EP US); C07D 491/147 (2013.01 - EP US); C07D 493/04 (2013.01 - EP US); C07D 493/14 (2013.01 - EP US); C07D 495/04 (2013.01 - EP US); C07D 498/04 (2013.01 - EP US); C12Q 1/6804 (2013.01 - US); C12Q 1/6841 (2013.01 - US); C12Q 1/6886 (2013.01 - US); G01N 33/5308 (2013.01 - US); G01N 33/532 (2013.01 - EP US); G01N 33/533 (2013.01 - EP US); G01N 33/58 (2013.01 - EP US); G01N 33/582 (2013.01 - EP US); G01N 33/583 (2013.01 - EP US); Y10S 435/961 (2013.01 - EP US); Y10S 530/807 (2013.01 - EP US)
Citation (search report)
- [Y] WO 03031419 A1 20030417 - DIMENSIONAL PHARM INC [US], et al
- [Y] US 2004157231 A1 20040812 - MELTOLA NIKO [FI], et al
- [Y] WO 2005064018 A2 20050714 - VENTANA MED SYST INC [US], et al
- [Y] EP 0354847 A2 19900214 - CYBERFLUOR INC [CA]
- [A] EP 0336192 A2 19891011 - IN VIVO DIAGNOSTIK THERAPIE [CH]
- [A] THOMPSON MARTIN: "Synthesis, photophysical effects, and DNA targeting properties of oxazole yellow-peptide bioconjugates", BIOCONJUGATE CHEMISTRY, vol. 17, no. 2, March 2006 (2006-03-01), pages 507 - 513, XP002566836, ISSN: 1043-1802
- [A] GRUCHALLA ET AL: "Sulfonamide-induced reactions in desensitized patients with AIDS-The role of covalent protein haptenation by sulfamethoxazole", JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, MOSBY, INC, US, vol. 101, no. 3, 1 March 1998 (1998-03-01), pages 371 - 378, XP005687575, ISSN: 0091-6749
- [A] MEEKINS CARLOS V ET AL: "Immunochemical analysis of sulfonamide drug allergy: Identification of sulfamethoxazole-substituted human serum proteins", JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, vol. 94, no. 6 PART 1, 1994, pages 1017 - 1024, XP002566837, ISSN: 0091-6749
- See references of WO 2008063378A2
Designated contracting state (EPC)
AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU LV MC MT NL PL PT RO SE SI SK TR
DOCDB simple family (publication)
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DOCDB simple family (application)
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