EP 2079458 A2 20090722 - TRANSDERMAL THERAPEUTIC SYSTEM WITH TWO-PHASE RELEASING PROFILE
Title (en)
TRANSDERMAL THERAPEUTIC SYSTEM WITH TWO-PHASE RELEASING PROFILE
Title (de)
TRANSDERMALES THERAPEUTISCHES SYSTEM MIT ZWEIPHASIGEM FREISETZUNGSPROFIL
Title (fr)
SYSTÈME THÉRAPEUTIQUE TRANSDERMIQUE À PROFIL DE LIBÉRATION EN DEUX PHASES
Publication
Application
Priority
- EP 2007058867 W 20070827
- DE 102006048130 A 20061006
Abstract (en)
[origin: WO2008043601A2] The present invention relates to a transdermal therapeutic system (TTS) comprising an impermeable covering layer, a matrix containing an ergolin compound of formula (I) or the physiologically compatible salt or derivative thereof, wherein R<SUP>1</SUP> represents an H atom or a halogen atom and R<SUP>2</SUP> an alkyl group with 1 to 4 carbon atoms and ------ a single or double bond, and a removable protective layer, the ergolin compound or the physiologically compatible salt or derivative thereof being stabilized by an antioxidant and a basic polymer. The TTS is characterized in that the matrix contains at least one hydrocarbon having 8 to 18 carbon atoms in a linear or branched chain and carrying a functional group at the end of the alkyl chain, and/or aloe vera oil so that, in a first phase (0-5 hours after application), only 0 to 20 % of the therapeutically desired steady state plasma concentration of the ergolin compound is achieved and, in a second phase (5-20 hours after application), the therapeutically desired steady state plasma concentration of the ergolin compound is achieved.
IPC 8 full level
A61K 9/70 (2006.01); A61K 47/06 (2006.01); A61K 47/10 (2006.01); A61K 47/16 (2006.01); A61K 47/32 (2006.01); A61K 47/44 (2006.01); C07D 457/00 (2006.01)
CPC (source: EP US)
A61K 9/7061 (2013.01 - EP US); A61K 31/48 (2013.01 - EP US); A61P 25/00 (2017.12 - EP); A61P 25/14 (2017.12 - EP); A61P 25/16 (2017.12 - EP)
Citation (search report)
See references of WO 2008043601A2
Designated contracting state (EPC)
AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU LV MC MT NL PL PT RO SE SI SK TR
DOCDB simple family (publication)
DE 102006048130 A1 20080410; AU 2007306582 A1 20080417; EP 2079458 A2 20090722; JP 2010505786 A 20100225; US 2010143475 A1 20100610; WO 2008043601 A2 20080417; WO 2008043601 A3 20080612; ZA 200901959 B 20100224
DOCDB simple family (application)
DE 102006048130 A 20061006; AU 2007306582 A 20070827; EP 07802907 A 20070827; EP 2007058867 W 20070827; JP 2009530821 A 20070827; US 31130507 A 20070827; ZA 200901959 A 20090320