Global Patent Index - EP 2079704 A4

EP 2079704 A4 20111116 - THERAPEUTIC COMPOUNDS

Title (en)

THERAPEUTIC COMPOUNDS

Title (de)

THERAPEUTISCHE VERBINDUNGEN

Title (fr)

COMPOSÉS THÉRAPEUTIQUES

Publication

EP 2079704 A4 20111116 (EN)

Application

EP 07755933 A 20070424

Priority

  • US 2007009862 W 20070424
  • US 79452506 P 20060425

Abstract (en)

[origin: WO2007127173A2] The invention provides compounds of formula I: wherein A, B, D, E, R<SUB>1</SUB>, R<SUB>2</SUB>, R<SUB>3</SUB>, R<SUB>4</SUB>, R<SUB>5</SUB>, X, and ----- have any values defined herein, as well as salts thereof. The compounds have activity as G-quadruplex DNA stabalizers and as anti-proliferative agents.

IPC 8 full level

C07D 498/22 (2006.01); A61K 31/424 (2006.01); A61P 35/00 (2006.01); C07D 513/22 (2006.01); C07D 515/22 (2006.01)

CPC (source: EP)

A61P 35/00 (2017.12); C07D 498/22 (2013.01); C07D 513/22 (2013.01); C07D 515/22 (2013.01)

Citation (search report)

  • [X] EP 1602659 A1 20051207 - SOSEI CO LTD [JP]
  • [X] S.K. CHATTOPADHYAY ET AL: "Efficient Construction of a Doubly Functionalized Trisoxazole Derivative Relevant to the Synthesis of the Novel Telomerase Inhibitor Telomestatinand its Analogues", SYNTHESIS, no. 8, April 2006 (2006-04-01), pages 1289 - 1294, XP002659448
  • [X] A.J. LUCKE ET AL: "Designing supramolecular structures from models of cyclic peptide scaffolds with heterocyclic constraints", JOURNAL OF MOLECULAR GRAPHICS AND MODELLING, no. 21, 2003, pages 341 - 355, XP002659449
  • [X] A.BERTRAM ET AL, TETRAHEDRON, vol. 59, no. 35, 25 August 2003 (2003-08-25), pages 6979 - 6990, XP004448505, ISSN: 0040-4020, DOI: 10.1016/S0040-4020(03)00821-4
  • [X] Y. SINGH ET AL: "Novel Cylindrical, Conical, and Macrocyclic Peptides from the Cyclooligomerization of Functionalized Thiazole Amino Acids", J. AM. CHEM. SOC., vol. 123, no. 2, 2001, pages 333 - 334, XP002659450 & Y. SINGH ET AL: "Supporting information: Novel Cylindrical, Conical, and Macrocyclic Peptides from the Cyclooligomerization of Functionalized Thiazole Amino Acids", J. AM. CHEM. SOC., vol. 123, no. 2, 2001, pages 1 - 13, XP002660487
  • [XP] G.S. MINHAS ET AL: "Synthesis and G-quadruplex stabilizing properties of a series of oxazole-containing macrocycles", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 16, no. 15, 1 August 2006 (2006-08-01), pages 3891 - 3895, XP025107094, ISSN: 0960-894X, [retrieved on 20060801], DOI: 10.1016/J.BMCL.2006.05.038
  • [XP] DATABASE CAPLUS [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; XP002659478, retrieved from STN Database accession no. 2006:1228832 & JP 2006316008 A 20061124 - SOOSEI KK, et al
  • [XP] T. DOI ET AL: "Total synthesis of (R)- Telomestatin", ORGANIC LETTERS, vol. 8, no. 18, 2006, pages 4165 - 4167, XP002659451
  • See references of WO 2007127173A2

Designated contracting state (EPC)

AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU LV MC MT NL PL PT RO SE SI SK TR

DOCDB simple family (publication)

WO 2007127173 A2 20071108; WO 2007127173 A3 20081218; WO 2007127173 A4 20090205; CA 2665818 A1 20071108; EP 2079704 A2 20090722; EP 2079704 A4 20111116

DOCDB simple family (application)

US 2007009862 W 20070424; CA 2665818 A 20070424; EP 07755933 A 20070424