EP 2079846 A4 20130807 - TARGETED GLYCOSAMINOGLYCAN POLYMERS BY POLYMER GRAFTING AND METHODS OF MAKING AND USING SAME
Title (en)
TARGETED GLYCOSAMINOGLYCAN POLYMERS BY POLYMER GRAFTING AND METHODS OF MAKING AND USING SAME
Title (de)
GEZIELTE GLYCOSAMINOGLYCAN-POLYMERE DURCH POLYMER-GRAFTING UND HERSTELLUNGS- UND ANWENDUNGSVERFAHREN DAFÜR
Title (fr)
POLYMÈRES DE GLYCOSAMINOGLYCANE CIBLÉS OBTENUS PAR GREFFAGE POLYMÈRE ET LEURS PROCÉDÉS DE FABRICATION ET D'UTILISATION
Publication
Application
Priority
- US 2007021213 W 20071003
- US 84903406 P 20061003
- US 92129607 P 20070330
Abstract (en)
[origin: WO2008130373A2] The present invention relates to methodology for polymer grafting by a polysaccharide synthase and, more particularly, polymer grafting using the hyaluronate or chondroitin or heparin/heparosan synthases from Pasteurella, in order to create a variety of glycosaminoglycan oligosaccharides having a natural or chimeric or hybrid sugar structure with a targeted size that are substantially monodisperse in size. The present invention also relates to methodology for polymer grafting by a polysachharide synthase to form glycosaminoglycan polymers having an unnatural structure.
IPC 8 full level
C12P 19/18 (2006.01); C08B 37/00 (2006.01); C08B 37/08 (2006.01); C12P 19/28 (2006.01)
CPC (source: EP)
C08B 37/0063 (2013.01); C08B 37/0069 (2013.01); C08B 37/0072 (2013.01); C08B 37/0075 (2013.01); C12P 19/26 (2013.01)
Citation (search report)
- [YD] KANE ET AL: "Functional characterization of PmHS1, a Pasteurella multocida heparosan synthase", THE JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 281, 7 September 2006 (2006-09-07), pages 33192 - 33197, XP002699111
- [YD] WILLIAMS ET AL: "Critical elements of oligosaccharide acceptor substrates for the Pasteurella multocida hyaluronan synthase", THE JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 281, 16 December 2005 (2005-12-16), pages 5391 - 5397, XP002482219
- [Y] JING ET AL: "Defined megadalton hyaluronan polymer standards", ANALYTICAL BIOCHEMISTRY, vol. 355, 23 June 2006 (2006-06-23), pages 183 - 188, XP024942078
- [YDP] PUMMILL ET AL: "The functional molecular mass of the Pasteurella hyaluronan synthase is a monomer", BIOCHIMICA ET BIOPHYSICA ACTA, vol. 1770, 4 October 2006 (2006-10-04), pages 286 - 290, XP005818421
- [YDP] TRACY ET AL: "Acceptor specificity of the Pasteurella hyaluronan and chondroitin synthases and production of chimeric glycosaminoglycans", THE JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 282, 10 November 2006 (2006-11-10), pages 337 - 344, XP002699112
- [YP] DEMCHENKO (EDITOR): "Fronteirs in Modern Carbohydrate Chemistry / ACS Symposium Series", vol. 960, 13 March 2007, ACS, article AVCI ET AL: "Enzymatic synthesis of glycosaminoglycans: Improving on nature", pages: 253 - 284, XP002699118
- [YP] SISMEY-RAGATZ ET AL: "Chemoenzymatic synthesis with distinct Pasteurella heparosan synthases", THE JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 282, 11 July 2007 (2007-07-11), pages 28321 - 28327, XP002699113
- [AP] LINHARDT ET AL: "Enzymatic synthesis of glycosaminoglycan heparin", SEMINARS IN THROMBOSIS AND HEMOSTASIS, vol. 33, July 2007 (2007-07-01), pages 453 - 465, XP008163151
- [L] KAMERLING (EDITOR-IN-CHIEF): "Comprehensive Glycoscience", vol. 3, 2007, ELSEVIER, ISBN: 978-0-4445-2746-2, article DEANGELIS: "Hyaluronan biosynthesis systems from microbes to man", pages: 325 - 341, XP002699207
- See references of WO 2008130373A2
Designated contracting state (EPC)
AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU LV MC MT NL PL PT RO SE SI SK TR
DOCDB simple family (publication)
WO 2008130373 A2 20081030; WO 2008130373 A3 20090305; AU 2007351891 A1 20081030; CA 2701601 A1 20081030; CA 2701601 C 20200630; EP 2079846 A2 20090722; EP 2079846 A4 20130807; EP 2690178 A1 20140129; EP 2690178 B1 20211222
DOCDB simple family (application)
US 2007021213 W 20071003; AU 2007351891 A 20071003; CA 2701601 A 20071003; EP 07874512 A 20071003; EP 13189930 A 20071003