EP 2084269 A2 20090805 - GENETIC ABLATION OF THE PRP GENE CELLS USING A TARGETED PROMOTER TRAP STRATEGY FOR PRODUCTION OF SERUM-FREE RECOMBINANT PROTEINS AS THERAPEUTICALS
Title (en)
GENETIC ABLATION OF THE PRP GENE CELLS USING A TARGETED PROMOTER TRAP STRATEGY FOR PRODUCTION OF SERUM-FREE RECOMBINANT PROTEINS AS THERAPEUTICALS
Title (de)
GENETISCHE ABLATION VON ZELLEN DES PRP-GENS MITHILFE EINER GEZIELTEN PROMOTER-AUFFANGSTRATEGIE ZUR HERSTELLUNG SERUMSFREIER REKOMBINANTER PROTEINE ALS BEHANDLUNGSMITTEL
Title (fr)
ABLATION GÉNÉTIQUE DU GÈNE PRP, CELLULES UTILISANT UN PIÈGE À PROMOTEUR CIBLÉ, STRATÉGIE POUR LA PRODUCTION DE PROTÉINES RECOMBINANTES EXEMPTES DE SÉRUM EN TANT QUE PRODUITS THÉRAPEUTIQUES
Publication
Application
Priority
- EP 2007062597 W 20071120
- EP 06124427 A 20061120
- EP 07847234 A 20071120
Abstract (en)
[origin: WO2008061995A2] The present invention provides a prion protein (PrP)-free immortalized somatic human cell line wherein both alleles of the PrP gene have been completely deleted by homologous recombination. The invention further provides a method for the production of said cell line and its use for producing human recombinant proteins which are suitable as biopharmaceuticals.
IPC 8 full level
C12N 5/06 (2006.01); C12N 5/071 (2010.01); C12N 5/10 (2006.01)
CPC (source: EP KR)
C12N 5/0686 (2013.01 - EP); C12N 5/10 (2013.01 - KR); C12N 15/10 (2013.01 - KR); C12N 15/11 (2013.01 - KR); C12N 2500/92 (2013.01 - EP); C12N 2500/95 (2013.01 - EP); C12N 2510/00 (2013.01 - EP); C12N 2510/02 (2013.01 - EP)
Citation (search report)
See references of WO 2008061995A2
Designated contracting state (EPC)
AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU LV MC MT NL PL PT RO SE SI SK TR
Designated extension state (EPC)
AL BA HR MK RS
DOCDB simple family (publication)
WO 2008061995 A2 20080529; WO 2008061995 A3 20080710; AU 2007324530 A1 20080529; BR PI0718989 A2 20140211; CA 2670003 A1 20080529; CN 101605891 A 20091216; EP 2084269 A2 20090805; IL 198770 A0 20110801; KR 20090106474 A 20091009; MX 2009005277 A 20090528; NO 20091875 L 20090728; RU 2009123458 A 20101227; ZA 200903429 B 20100428
DOCDB simple family (application)
EP 2007062597 W 20071120; AU 2007324530 A 20071120; BR PI0718989 A 20071120; CA 2670003 A 20071120; CN 200780046653 A 20071120; EP 07847234 A 20071120; IL 19877009 A 20090514; KR 20097012589 A 20071120; MX 2009005277 A 20071120; NO 20091875 A 20090513; RU 2009123458 A 20071120; ZA 200903429 A 20090519