Global Patent Index - EP 2085486 A1

EP 2085486 A1 20090805 - Methods and kits for the rapid determination of patients at high risk of death during septic shock

Title (en)

Methods and kits for the rapid determination of patients at high risk of death during septic shock

Title (de)

Verfahren und Kits zur schnellen Bestimmung von Patienten mit einem hohen Todesrisiko während eines septischen Schocks

Title (fr)

Procédés et kits pour la détermination rapide de patients à haut risque de mort pendant un choc septique

Publication

EP 2085486 A1 20090805 (EN)

Application

EP 08290090 A 20080201

Priority

EP 08290090 A 20080201

Abstract (en)

The present invention relates to the field of treatment of serious medical syndromes such as severe sepsis and septic shock. In particular, the present invention provides methods and kits to obtain an early evaluation of mortality risk and help therapeutic decisions for patients in severe sepsis with two organ failures, for example for patients in septic shock with one additional organ failure. The methods of the invention are based on the analysis of an expression profile of one or several genes selected in the group consisting of HLA-DRB4, FOSB, GPR109B, RBP7, TLR7, IL15, HLA-C, AMFR, LOC96610, IRF5, MGC29506, EDG3, IGLV1-44, IFIT2, IFI44, EPSTI1, TNFRSF17, AREG, THBS1, CTLS1, TFPI, PHACTR2, PFKFB2 and CHIT1.

IPC 8 full level

C12Q 1/68 (2006.01)

CPC (source: EP US)

C12Q 1/6883 (2013.01 - EP US); C12Q 2600/106 (2013.01 - EP US); C12Q 2600/118 (2013.01 - EP US); C12Q 2600/158 (2013.01 - EP US)

Citation (applicant)

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Citation (search report)

  • [X] WO 2006079760 A1 20060803 - BIOMERIEUX SA [FR], et al
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  • [A] CZERWONY GRIT ET AL: "Differential surface expression of HLA-DRB1 and HLA-DRB4 among peripheral blood cells of DR4 positive individuals", HUMAN IMMUNOLOGY, vol. 60, no. 1, January 1999 (1999-01-01), pages 1 - 9, XP002488317, ISSN: 0198-8859
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  • [AD] BONE R C ET AL: "DEFINITIONS FOR SEPSIS AND ORGAN FAILURE AND GUIDELINES FOR THE USE OF INNOVATIVE THERAPIES IN SEPSIS", CHEST, THE COLLEGE, CHICAGO, IL, US, vol. 101, no. 6, 1 June 1992 (1992-06-01), pages 1644 - 1655, XP009044010, ISSN: 0012-3692
  • [AD] VINCENT J-L ET AL: "THE SOFA (SEPSIS-RELATED ORGAN FAILURE ASSESSMENT) SCORE TO DESCRIBE ORGAN DYSFUNCTION/FAILURE", INTENSIVE CARE MEDICINE, BERLIN, DE, vol. 22, no. 7, 1 July 1996 (1996-07-01), pages 707 - 710, XP009037295, ISSN: 0342-4642

Designated contracting state (EPC)

AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MT NL NO PL PT RO SE SI SK TR

Designated extension state (EPC)

AL BA MK RS

DOCDB simple family (publication)

EP 2085486 A1 20090805; CA 2713839 A1 20090806; EP 2245194 A2 20101103; JP 2011510650 A 20110407; US 2011190143 A1 20110804; WO 2009095786 A2 20090806; WO 2009095786 A3 20091105

DOCDB simple family (application)

EP 08290090 A 20080201; CA 2713839 A 20090130; EP 09705033 A 20090130; IB 2009000292 W 20090130; JP 2010544810 A 20090130; US 86553609 A 20090130