EP 2089107 A2 20090819 - NEAR-INFRARED ELECTROMAGNETIC MODIFICATION OF CELLULAR STEADY- STATE MEMBRANE POTENTIALS
Title (en)
NEAR-INFRARED ELECTROMAGNETIC MODIFICATION OF CELLULAR STEADY- STATE MEMBRANE POTENTIALS
Title (de)
ELEKTROMAGNETISCHE NAHINFRAROTÄNDERUNG VON STATIONÄREM ZELLMEMBRANPOTENZIAL
Title (fr)
MODIFICATION ÉLECTROMAGNÉTIQUE PROCHE INFRAROUGE DE POTENTIELS DE MEMBRANE STATIONNAIRES CELLULAIRES
Publication
Application
Priority
- US 2007087264 W 20071212
- US 87442406 P 20061212
- US 98134007 A 20071031
- US 98143107 A 20071031
- US 98148607 A 20071031
Abstract (en)
[origin: WO2008073979A2] Systems and methods are disclosed herein for applying near-infrared optical energies and dosimetries to alter the bioenergetic steady-state trans-membrane and mitochondrial potentials (??-steady) of all irradiated cells through an optical depolarization effect. This depolarization causes a concomitant decrease in the absolute value of the trans-membrane potentials ?? of the irradiated mitochondrial and plasma membranes. Many cellular anabolic reactions and drug-resistance mechanisms can be rendered less functional and/or mitigated by a decrease in a membrane potential ??, the affiliated weakening of the proton motive force ?p, and the associated lowered phosphorylation potential ?Gp. Within the area of irradiation exposure, the decrease in membrane potentials ?? will occur in bacterial, fungal and mammalian cells in unison. This membrane depolarization provides the ability to potentiate antimicrobial, antifungal and/or antineoplastic drugs against only targeted undesirable cells.
IPC 8 full level
A61N 5/06 (2006.01)
CPC (source: EP KR)
A61K 41/0057 (2013.01 - EP); A61K 41/17 (2020.01 - EP); A61N 5/06 (2013.01 - EP KR); A61N 5/0624 (2013.01 - EP); A61N 5/067 (2021.08 - EP); A61P 31/04 (2017.12 - EP); A61P 31/10 (2017.12 - EP); A61P 35/00 (2017.12 - EP); A61P 43/00 (2017.12 - EP); C12N 5/04 (2013.01 - KR); C12N 13/00 (2013.01 - EP); A61N 5/0601 (2013.01 - EP)
Citation (search report)
See references of WO 2008073979A2
Designated contracting state (EPC)
AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU LV MC MT NL PL PT RO SE SI SK TR
DOCDB simple family (publication)
WO 2008073979 A2 20080619; WO 2008073979 A3 20081023; AU 2007333073 A1 20080619; CA 2670711 A1 20080619; EP 2089107 A2 20090819; JP 2010512232 A 20100422; KR 20090097925 A 20090916
DOCDB simple family (application)
US 2007087264 W 20071212; AU 2007333073 A 20071212; CA 2670711 A 20071212; EP 07865581 A 20071212; JP 2009541559 A 20071212; KR 20097014482 A 20071212