EP 2091611 A2 20090826 - NEW DRUG FOR TREATING GASTRIC CANCER
Title (en)
NEW DRUG FOR TREATING GASTRIC CANCER
Title (de)
NEUES ARZNEIMITTEL ZUR BEHANDLUNG VON MAGENKREBS
Title (fr)
NOUVEAU MÉDICAMENT POUR LE TRAITEMENT D'UN CANCER GASTRIQUE
Publication
Application
Priority
- FR 2007052575 W 20071220
- FR 0655835 A 20061221
Abstract (en)
[origin: FR2910324A1] A molecule (I) that blocks the inflammatory or immunostimulant activity of interleukin 17 or blocks the action of an interleukin 17 receptor is used to prepare a medicament for inhibiting, preventing or treating stomach cancer. An independent claim is also included for a pharmaceutical composition comprising (I) and a carrier. ACTIVITY : Cytostatic. MECHANISM OF ACTION : Interleukin 17 blocker; Interleukin receptor blocker. Activation of p65 and c-Jun induced by interleukin 17A in AGS human stomach cancer cells was reduced by 97% and 80% respectively when the cells were transfected with small interfering RNA molecules comprising nucleotides 1623-1641 of interleukin 17 receptor A and nucleotides 985-1003 of interleukin 17 receptor C.
IPC 8 full level
A61P 35/00 (2006.01); A61K 39/395 (2006.01); C12N 15/11 (2006.01)
CPC (source: EP US)
A61P 35/00 (2017.12 - EP); C07K 14/54 (2013.01 - EP US); C07K 14/7155 (2013.01 - EP US)
Citation (search report)
See references of WO 2008087329A2
Designated contracting state (EPC)
AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU LV MC MT NL PL PT RO SE SI SK TR
DOCDB simple family (publication)
FR 2910324 A1 20080627; FR 2910324 B1 20090306; EP 2091611 A2 20090826; US 2010055108 A1 20100304; WO 2008087329 A2 20080724; WO 2008087329 A3 20081127
DOCDB simple family (application)
FR 0655835 A 20061221; EP 07871986 A 20071220; FR 2007052575 W 20071220; US 31277407 A 20071220