Global Patent Index - EP 2097410 A4

EP 2097410 A4 20091125 - HETEROARYL-PYRAZOLE DERIVATIVES AS CANNABINOID CB1 RECEPTOR ANTAGONISTS

Title (en)

HETEROARYL-PYRAZOLE DERIVATIVES AS CANNABINOID CB1 RECEPTOR ANTAGONISTS

Title (de)

HETEROARYLPYRAZOLDERIVATE ALS ANTAGONISTEN DES CANNABINOID-CB1-REZEPTORS

Title (fr)

DÉRIVÉS D'HÉTÉROARYL-PYRAZOLE UTILISÉS EN TANT QU'ANTAGONISTES DU RÉCEPTEUR CB1 DES CANNABINOÏDES

Publication

EP 2097410 A4 20091125 (EN)

Application

EP 07833072 A 20070928

Priority

  • KR 2007004754 W 20070928
  • US 54126906 A 20060929
  • KR 20060132606 A 20061222

Abstract (en)

[origin: WO2008039023A1] A heteroaryl-pyrazole compound of formula (I) or a pharmaceutically acceptable salt thereof is effective as a cannabinoid CB1 receptor inverse agonist or antagonist, which is useful for preventing or treating obesity and obesity-related metabolic disorders. The present invention also provides a method for preparing the inventive heteroaryl-pyrasole compounds or a pharmaceutically acceptable salt thereof, a pharmaceutical composition containing same, and a method for preventing or treating obesity and obesity-related metabolic disorders.

IPC 8 full level

C07D 419/04 (2006.01); A61K 31/415 (2006.01); A61K 31/4155 (2006.01); A61P 3/04 (2006.01); A61P 29/00 (2006.01); C07D 413/04 (2006.01)

CPC (source: EP KR)

A61P 3/04 (2017.12 - EP); A61P 29/00 (2017.12 - EP); A61P 43/00 (2017.12 - EP); C07D 401/14 (2013.01 - EP); C07D 403/04 (2013.01 - EP KR); C07D 403/14 (2013.01 - EP); C07D 405/14 (2013.01 - EP); C07D 409/14 (2013.01 - EP); C07D 413/04 (2013.01 - EP KR); C07D 413/14 (2013.01 - EP); C07D 417/04 (2013.01 - EP KR); C07D 417/14 (2013.01 - EP)

Citation (search report)

  • [X] WO 2005018645 A1 20050303 - PFIZER PROD INC [US], et al
  • [X] US 2004077650 A1 20040422 - DOW ROBERT L [US]
  • [X] WO 02100826 A2 20021219 - CYTOVIA INC [US], et al
  • [X] DATABASE CA [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; MASLIVETS, A. N. ET AL: "Five-membered 2,3-dioxo heterocycles. XI. Synthesis and chemical transformations of .beta.-aroylhydrazides of aroylpyruvic acids", XP002550421, retrieved from STN Database accession no. 1990:55776 & ZHURNAL ORGANICHESKOI KHIMII , 25(5), 1039-45 CODEN: ZORKAE; ISSN: 0514-7492, 1989
  • [X] DATABASE CA [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; SHIMANSKAYA, N. P. ET AL: "Polarographic study of derivatives of .DELTA.2-pyrazoline", XP002550422, retrieved from STN Database accession no. 1968:512873 & ZHURNAL OBSHCHEI KHIMII , 38(8), 1676-9 CODEN: ZOKHA4; ISSN: 0044-460X, 1968
  • [X] DATABASE CA [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; SHKUMAT, A. P.: "Search for new luminophores with predetermined physicochemical and chemical properties. I. 1,3,5-Triarylpyrazoles", XP002550423, retrieved from STN Database accession no. 2000:55923 & VISNIK KHARKIVS'KOGO UNIVERSITETU , (2(CHEM.)), 121-125 CODEN: VKSGA3; ISSN: 0453-8048, 1998
  • [X] DATABASE CA [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; BERGEON, MARIE T. ET AL: "Sulfurated organic compounds. VIII. Reaction of phenylhydrazine with 3-aryl-1,2-dithiolylium bisulfates and 3,5-diaryl-1,2-dithiolylium perchlorates. 3-Aryl-1-phenylpyrazoles, 5-aryl-1-phenylpyrazoles, and 3,5-diaryl-1-phenylpyrazoles", XP002550424, retrieved from STN Database accession no. 1971:420283 & BULLETIN DE LA SOCIETE CHIMIQUE DE FRANCE , (3), 917-24 CODEN: BSCFAS; ISSN: 0037-8968, 1971
  • [X] DATABASE CA [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; FINAR, I. L.: "Preparation and properties of some bipyrazolyls", XP002550425, retrieved from STN Database accession no. 1956:12288 & JOURNAL OF THE CHEMICAL SOCIETY 1205-8 CODEN: JCSOA9; ISSN: 0368-1769, 1955
  • [X] DATABASE CA [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; ARRIETA, ANA ET AL: "Efficient tautomerization hydrazone-azomethine imine under microwave irradiation. Synthesis of [4,3'] and [5,3']bipyrazoles", XP002550426, retrieved from STN Database accession no. 1998:678997 & TETRAHEDRON , 54(43), 13167-13180 CODEN: TETRAB; ISSN: 0040-4020, 1998
  • [X] DATABASE CA [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; SHIRONINA, T. M. ET AL: "1,3,4,6-Tetracarbonyl compounds: IV. Reaction of 3,4-dihydroxy-2,4-hexadiene-1,6-diones with hydrazine and arylhydrazines", XP002550427, retrieved from STN Database accession no. 2002:136610 & RUSSIAN JOURNAL OF ORGANIC CHEMISTRY (TRANSLATION OF ZHURNAL ORGANICHESKOI KHIMII) , 37(10), 1486-1494 CODEN: RJOCEQ; ISSN: 1070-4280, 2001
  • [X] DATABASE CA [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; PFLEGER, ROBERT ET AL: ".alpha.-Acylaminoacrylic acid. VII. The action of hypobromite on .alpha.-acetamidocinnamic acid", XP002550428, retrieved from STN Database accession no. 1958:113664 & CHEMISCHE BERICHTE , 90, 2401-4 CODEN: CHBEAM; ISSN: 0009-2940, 1957
  • [X] DATABASE CA [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; MILLER, SIDNEY I. ET AL: "Mass spectra of 1,2,3-triazoles", XP002550429, retrieved from STN Database accession no. 1979:473771 & JOURNAL OF THE CHEMICAL SOCIETY, PERKIN TRANSACTIONS 1: ORGANIC AND BIO-ORGANIC CHEMISTRY (1972-1999) , (1), 15-19 CODEN: JCPRB4; ISSN: 0300-922X, 1979
  • [X] DATABASE CA [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; CARRILLO, J. R. ET AL: "A complete model for the prediction of 1H- and 13C-NMR chemical shifts and torsional angles in phenyl-substituted pyrazoles", XP002550430, retrieved from STN Database accession no. 2001:321317 & TETRAHEDRON , 57(19), 4179-4187 CODEN: TETRAB; ISSN: 0040-4020, 2001
  • [X] DATABASE CA [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; FINAR, I. L. ET AL: "Preparation of some pyrazole derivatives", XP002550431, retrieved from STN Database accession no. 1959:94763 & JOURNAL OF THE CHEMICAL SOCIETY 1819-23 CODEN: JCSOA9; ISSN: 0368-1769, 1959
  • See references of WO 2008039023A1

Designated contracting state (EPC)

AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU LV MC MT NL PL PT RO SE SI SK TR

DOCDB simple family (publication)

WO 2008039023 A1 20080403; CN 101528740 A 20090909; CN 101528740 B 20120919; EP 2097410 A1 20090909; EP 2097410 A4 20091125; JP 2010504961 A 20100218; JP 5269795 B2 20130821; KR 101100028 B1 20111229; KR 20090061076 A 20090615

DOCDB simple family (application)

KR 2007004754 W 20070928; CN 200780036330 A 20070928; EP 07833072 A 20070928; JP 2009530273 A 20070928; KR 20097008743 A 20070928