EP 2100139 A2 20090916 - BIOLOGICALLY ACTIVE COMPOSITIONS, METHODS FOR PRODUCING THE SAME AND BIOLOGICAL APPLICATIONS
Title (en)
BIOLOGICALLY ACTIVE COMPOSITIONS, METHODS FOR PRODUCING THE SAME AND BIOLOGICAL APPLICATIONS
Title (de)
BIOLOGISCH AKTIVE ZUSAMMENSETZUNGEN SOWIE VERFAHREN ZU IHRER HERSTELLUNG UND BIOLOGISCHEN ANWENDUNG
Title (fr)
COMPOSITIONS BIOLOGIQUEMENT ACTIVES, PROCÉDÉ POUR LEUR OBTENTION, ET APPLICATIONS BIOLOGIQUES
Publication
Application
Priority
- FR 2007001869 W 20071113
- FR 0609930 A 20061114
- FR 0704278 A 20070615
Abstract (en)
[origin: FR2908310A1] Use of a product from plants comprising extracts, fractions and/or molecules as G-protein coupled receptor (TGR5) specific agonist, having minimum effective concentration (EC50) of greater/equal to TGR5 natural ligand comprising litocholic acid, not activate the farnesoid X receptor (FXR) nuclear receptor, inducing a reduction of weight gain induced by a fatty food to a model, who has metabolic syndrome, and a reduction of mass of fatty cell of epididymis in the models, and inducing a improvement of glucose tolerance, is claimed. Use of a product from plants comprising extracts, fractions and/or molecules as G-protein coupled receptor (TGR5) specific agonist, where the plant extract or fraction is obtained from the extract or the molecules is obtained by the extract or fractions, having minimum effective concentration (EC50) of greater or equal to TGR5 natural ligand, such as litocholic acid, not activate the farnesoid X receptor (FXR) nuclear receptor, inducing a reduction of weight gain induced by a fatty food to a model, who has metabolic syndrome, as well as a reduction of mass of fatty cell of epididymis in the models, and inducing a improvement of glucose tolerance, is claimed. ACTIVITY : Metabolic; Anorectic; Antidiabetic. MECHANISM OF ACTION : G-protein coupled receptor agonist. Tests details are described but no results given.
IPC 8 full level
G01N 33/50 (2006.01); A61K 31/19 (2006.01); A61K 36/00 (2006.01); A61K 36/185 (2006.01); A61K 36/52 (2006.01); A61K 36/63 (2006.01); A61K 36/73 (2006.01); A61K 45/00 (2006.01); A61P 3/00 (2006.01); A61P 3/04 (2006.01); A61P 3/10 (2006.01)
CPC (source: EP)
A61K 31/19 (2013.01); A61K 36/00 (2013.01); A61K 36/185 (2013.01); A61K 36/45 (2013.01); A61K 36/52 (2013.01); A61K 36/63 (2013.01); A61K 36/73 (2013.01); A61K 38/40 (2013.01); A61P 3/00 (2017.12); A61P 3/04 (2017.12); A61P 3/10 (2017.12); G01N 33/6893 (2013.01); G01N 2333/726 (2013.01); G01N 2407/00 (2013.01); G01N 2800/02 (2013.01); G01N 2800/04 (2013.01)
Citation (search report)
See references of WO 2008074935A2
Citation (third parties)
Third party :
- DATABASE TKDL [online] "Akharotagunaah", XP003030914, Database accession no. RS/5029 & "Brhat Nighantu Ratnakara (Saligramanighantubhusanam)", vol. 4, part VII 1997, pages: 456
- DATABASE TKDL [online] "Aksoda (Bijadala)", XP003030915, Database accession no. RG/3581 & GOVT OF INDIA: "The Ayurvedic Pharmacopoiea of India", vol. II, part 1 1999, pages: 3 - 4
- DATABASE TKDL [online] "Dawa-e-shajana/sohanjana Barae Tauleed-e- Mani", XP003030916, Database accession no. AN2/965O & MOHAMMAD NAJMUL GHANI KHAN: "Khazaain-al-Advia", vol. II, 1911, pages: 948
- DATABASE TKDL [online] "Ghiza-e-dawaae", XP003030917, Database accession no. AH3/4016 & ALI IBN-E-ABBAAS MAJOOSI: "Kaamil-al-Sena'ah", part II 2005, pages: 410
- DATABASE TKDL [online] "Dawa-e- Falona Musakkin", XP003030918, Database accession no. MH2/13I & ZIYA AL- DIN ABDULLAH IBN AL- BAITAR: "Al-Jaam'e-li-Mufradaat-al-Advia-wal-Aghzia", vol. IV, 1874, pages: 10 - 11
Designated contracting state (EPC)
AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU LV MC MT NL PL PT RO SE SI SK TR
DOCDB simple family (publication)
FR 2908310 A1 20080516; FR 2908310 B1 20090710; EP 2100139 A2 20090916; JP 2010509390 A 20100325; WO 2008074935 A2 20080626; WO 2008074935 A3 20080912
DOCDB simple family (application)
FR 0704278 A 20070615; EP 07870278 A 20071113; FR 2007001869 W 20071113; JP 2009536760 A 20071113