Global Patent Index - EP 2103602 A1

EP 2103602 A1 20090923 - Novel 1,2,4-triazole derivatives and process of manufacturing thereof

Title (en)

Novel 1,2,4-triazole derivatives and process of manufacturing thereof

Title (de)

Neuartige 1,2,4-Triazol-Derivate und Herstellungsverfahren dafür

Title (fr)

Nouveaux dérivés de triazole 1,2,4 et leur processus de fabrication

Publication

EP 2103602 A1 20090923 (EN)

Application

EP 08102647 A 20080317

Priority

EP 08102647 A 20080317

Abstract (en)

The invention discloses a process of manufacturing 1,2,4-triazole derivatives comprising steps (a) to (e). The invention further discloses novel 1,2,4-triazoie derivatives and their use as medicaments.

IPC 8 full level

A61K 31/4196 (2006.01); A61P 5/06 (2006.01); C07D 249/08 (2006.01)

CPC (source: EP US)

A61P 1/02 (2017.12 - EP); A61P 1/04 (2017.12 - EP); A61P 3/00 (2017.12 - EP); A61P 3/04 (2017.12 - EP); A61P 3/06 (2017.12 - EP); A61P 3/10 (2017.12 - EP); A61P 5/06 (2017.12 - EP); A61P 7/06 (2017.12 - EP); A61P 9/00 (2017.12 - EP); A61P 9/02 (2017.12 - EP); A61P 11/00 (2017.12 - EP); A61P 13/12 (2017.12 - EP); A61P 17/02 (2017.12 - EP); A61P 19/00 (2017.12 - EP); A61P 19/08 (2017.12 - EP); A61P 19/10 (2017.12 - EP); A61P 21/00 (2017.12 - EP); A61P 25/00 (2017.12 - EP); A61P 25/18 (2017.12 - EP); A61P 25/20 (2017.12 - EP); A61P 25/22 (2017.12 - EP); A61P 25/24 (2017.12 - EP); A61P 25/28 (2017.12 - EP); A61P 35/00 (2017.12 - EP); A61P 37/04 (2017.12 - EP); A61P 43/00 (2017.12 - EP); C07D 249/08 (2013.01 - EP US)

Citation (applicant)

  • WO 0054729 A2 20000921 - BRISTOL MYERS SQUIBB CO [US]
  • WO 0136395 A1 20010525 - JANSSEN PHARMACEUTICA NV [BE], et al
  • WO 2007020013 A2 20070222 - ZENTARIS GMBH [DE], et al
  • US 4411890 A 19831025 - MOMANY FRANK A [US]
  • WO 8907110 A1 19890810 - EASTMAN KODAK CO [US]
  • WO 8907111 A1 19890810 - EASTMAN KODAK CO [US]
  • WO 0196300 A1 20011220 - ZENTARIS AG [DE]
  • US 6548529 B1 20030415 - ROBL JEFFREY A [US], et al
  • US 5624941 A 19970429 - BARTH FRANCIS [FR], et al
  • US 6184231 B1 20010206 - HEWAWASAM PIYASENA [US], et al
  • US 5612359 A 19970318 - MURUGESAN NATESAN [US]
  • US 6043265 A 20000328 - MURUGESAN NATESAN [US], et al
  • WO 0001389 A1 20000113 - BRISTOL MYERS SQUIBB CO [US]
  • AVALOS M ET AL., TETRAHEDON, vol. 53, no. 42, 1997, pages 14463 - 14480
  • HITOTSUYANAGI Y ET AL., J. ORG. CHEM., vol. 67, 2002, pages 3266 - 3271
  • BOEGLIN D, ORG. LETT., vol. 5, no. 23, 2003, pages 4465 - 4468
  • "The Practice of Medicinal Chemistry", vol. 31, 1996, ACADEMIC PRESS
  • "Design of Prodrugs", 1985, ELSEVIER
  • "A Textbook of Drug Design and Development", vol. 5, 1991, HARWOOD ACADEMIC PUBLISHERS, pages: 113 - 191
  • EDWARDS, J. P. ET AL., BIO. MED. CHEM. LET., vol. 9, 1999, pages 1003 - 1008
  • HAMANN, L. G ET AL., J. MED. CHEM., vol. 12, 1999, pages 210 - 212
  • "Ullman's Ency clopedia of Technical Chemistry", vol. 4, 1953, pages: 1 - 39
  • JOURNAL OF PHARMACEUTICAL SCIENCES, vol. 52, 1963, pages 918
  • CZETSCH-LINDENWALD: "Hilfsstoffe fur Pharmazie and angrenzende Gebiete", PHARM. IND., vol. 2, 1961, pages 72
  • DR. H.P. FIEDLER: "Lexikon der Hilfsstoffe fur Pharmazie, Kosmetik and angrenzende Gebiete", 1971
  • GUERLAVAIS ET AL., J. MED. CHEM, vol. 46, 2003, pages 1191 - 1203
  • LAZARENO S; BIRDSALL NJ, TRENDS PHARMACOL SCI, vol. 14, no. 6, 1993, pages 237 - 239

Citation (search report)

  • [DYX] WO 2007020013 A2 20070222 - ZENTARIS GMBH [DE], et al
  • [Y] EP 1757290 A1 20070228 - ZENTARIS GMBH [DE], et al
  • [Y] PAULVANNAN K ET AL: "An Improved Synthesis of 1,2,4-Triazoles using Ag2CO3", TETRAHEDRON, vol. 56, no. 41, 6 October 2000 (2000-10-06), ELSEVIER SCIENCE PUBLISHERS, AMSTERDAM, NL, pages 8071 - 8076, XP004217678, ISSN: 0040-4020
  • [A] Y. HITOTSUYANAGI: "A cis amide bond surrogate incorporating 1,2,4-triazole", J. ORG. CHEM., vol. 67, no. 10, 2002, pages 3266 - 3271, XP002490024
  • [Y] A. MOULIN ET AL.: "Trisubstituted 1,2,4-triazoles as ligands for the ghrelin receptor: On the significance of the orientation and substitution at position 3.", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 18, no. 1, 1 January 2008 (2008-01-01), PERGAMON, ELSEVIER SCIENCE, GB, pages 164 - 168, XP022410876, ISSN: 0960-894X
  • [Y] L. DEMANGE ET AL.: "Synthesis and pharmacologocal in vitro and in vivo evaluations of novel triazole derivatives as ligands of the ghrelin receptor. 1", J. MED. CHEM., vol. 50, no. 8, 2007, pages 1939 - 1957, XP002504163

Designated contracting state (EPC)

AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MT NL NO PL PT RO SE SI SK TR

Designated extension state (EPC)

AL BA MK RS

DOCDB simple family (publication)

EP 2103602 A1 20090923; AR 070918 A1 20100512; CA 2718744 A1 20090924; EP 2265593 A1 20101229; EP 2265593 B1 20130828; EP 2604594 A1 20130619; ES 2436623 T3 20140103; JP 2011514376 A 20110506; KR 20110074954 A 20110705; MX 2010010099 A 20101125; TW 201000467 A 20100101; US 2009239877 A1 20090924; WO 2009115503 A1 20090924

DOCDB simple family (application)

EP 08102647 A 20080317; AR P090100946 A 20090317; CA 2718744 A 20090317; EP 09721415 A 20090317; EP 13001319 A 20090317; EP 2009053107 W 20090317; ES 09721415 T 20090317; JP 2011500185 A 20090317; KR 20107023191 A 20090317; MX 2010010099 A 20090317; TW 98108609 A 20090317; US 40558809 A 20090317