EP 2108015 A4 20110601 - AZACYCLOALKANE DERIVATIVES AS INHIBITORS OF STEAROYL-COENZYME A DELTA-9 DESATURASE

Title (en)

AZACYCLOALKANE DERIVATIVES AS INHIBITORS OF STEAROYL-COENZYME A DELTA-9 DESATURASE

Title (de)

AZACYCLOALKANDERIVATE ALS INHIBITOREN VON STEAROYL-COENZYM-A-DELTA-9-DESATURASE

Title (fr)

DÉRIVÉS DE ZACYCLOALKANE UTILISÉS COMME INHIBITEURS DE STEAROYL-COENZYME A DELTA-9 DESATURASE

Publication

EP 2108015 A4 20110601 (EN)

Application

EP 08706318 A 20080124

Priority

CA 2008000171 W 20080124
US 89767507 P 20070126

Abstract (en)

[origin: WO2008089580A1] Azacycloalkane derivatives of structural formula I are selective inhibitors of stearoyl-coenzyme A delta-9 desaturase (SCD1) relative to other known stearoyl-coenzyme A desaturases. The compounds of the present invention are useful for the prevention and treatment of conditions related to abnormal lipid synthesis and metabolism, including cardiovascular disease, such as atherosclerosis; obesity; diabetes; neurological disease; metabolic syndrome; insulin resistance; and liver steatosis.

IPC 8 full level

A61K 31/497 (2006.01); A61K 31/506 (2006.01); A61K 31/53 (2006.01); A61P 3/04 (2006.01); A61P 3/10 (2006.01); C07D 401/14 (2006.01)

CPC (source: EP US)

A61P 1/16 (2017.12 - EP); A61P 3/00 (2017.12 - EP); A61P 3/04 (2017.12 - EP); A61P 3/06 (2017.12 - EP); A61P 3/10 (2017.12 - EP); A61P 9/10 (2017.12 - EP); A61P 43/00 (2017.12 - EP); C07D 401/14 (2013.01 - EP US); C07D 403/14 (2013.01 - EP US)

Citation (search report)

[ID] WO 2005011657 A2 20050210 - XENON PHARMACEUTICALS INC [CA], et al
See references of WO 2008089580A1

Designated contracting state (EPC)

AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MT NL NO PL PT RO SE SI SK TR

DOCDB simple family (publication)

WO 2008089580 A1 20080731; AR 064965 A1 20090506; AU 2008209295 A1 20080731; CA 2676199 A1 20080731; CL 2008000198 A1 20080530; CN 101641347 A 20100203; EP 2108015 A1 20091014; EP 2108015 A4 20110601; JP 2010516714 A 20100520; PE 20081704 A1 20081207; TW 200838533 A 20081001; US 2008182838 A1 20080731; US 2009270434 A1 20091029; US 7582633 B2 20090901

DOCDB simple family (application)

CA 2008000171 W 20080124; AR P080100238 A 20080118; AU 2008209295 A 20080124; CA 2676199 A 20080124; CL 2008000198 A 20080124; CN 200880009274 A 20080124; EP 08706318 A 20080124; JP 2009546626 A 20080124; PE 2008000179 A 20080123; TW 97102225 A 20080121; US 1130908 A 20080125; US 49847609 A 20090707