EP 2111404 A1 20091028 - METHOD FOR PRODUCTION OF ARYL-SUBSTITUTED ANNELATED PYRIMIDINES
Title (en)
METHOD FOR PRODUCTION OF ARYL-SUBSTITUTED ANNELATED PYRIMIDINES
Title (de)
VERFAHREN ZUR HERSTELLUNG ARYLSUBSTITUIERTER ANELLIERTER PYRIMIDINE
Title (fr)
PROCÉDÉ DE PRODUCTION DE PYRIMIDINES ANNELÉES, SUBSTITUÉES PAR ARYLE
Publication
Application
Priority
- EP 2008050254 W 20080110
- EP 07100430 A 20070111
- EP 08701400 A 20080110
Abstract (en)
[origin: WO2008084082A1] The invention relates to a method for production of aryl-substituted annelated pyrimidines of general formula (I), where L<SUP>1</SUP> to L<SUP>5</SUP>=<SUP/>H, halogen, CN, NO<SUB>2</SUB>, C<SUB>1</SUB>-C<SUB>4 </SUB>alkyl, C<SUB>1</SUB>-C<SUB>4 </SUB>haloalkyl, C<SUB>1</SUB>-C<SUB>4 </SUB>alkoxy, C<SUB>1</SUB>-C<SUB>4 </SUB>haloalkoxy, etc., Y<SUP>1</SUP> to Y<SUP>3</SUP> = C-R<SUP>?</SUP> or N, R<SUP>?</SUP> = H or optionally substituted C<SUB>1</SUB>-C<SUB>4 </SUB>alkyl or two adjacent R<SUP>?</SUP> groups together form a ring, X = OH, Cl or Br, comprising: i) the reaction of a 2-phenylmalonate with a compound (III) or a tautomer thereof, in the presence of a suitable base, with continuous removal of the alcohol of formula R-OH, formed during the reaction, under reduced pressure, to give a compound of formula (I) or a salt thereof, where X = OH and in the case that X in compounds of general formula (I) = chlorine or bromine, ii) the reaction of the compounds of formula (I) obtained in step (i) or the salt thereof with a halogenating agent.
IPC 8 full level
C07D 487/04 (2006.01)
CPC (source: EP US)
C07D 487/04 (2013.01 - EP US)
Citation (search report)
See references of WO 2008084082A1
Designated contracting state (EPC)
AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MT NL NO PL PT RO SE SI SK TR
DOCDB simple family (publication)
WO 2008084082 A1 20080717; CN 101583613 A 20091118; EP 2111404 A1 20091028; JP 2010515706 A 20100513; US 2010087640 A1 20100408
DOCDB simple family (application)
EP 2008050254 W 20080110; CN 200880002186 A 20080110; EP 08701400 A 20080110; JP 2009545180 A 20080110; US 52187708 A 20080110