EP 2115122 A4 20101229 - EXPRESSION OF HLA PROTEINS ON NON-HUMAN CELLS
Title (en)
EXPRESSION OF HLA PROTEINS ON NON-HUMAN CELLS
Title (de)
EXPRESSION VON HLA-PROTEINEN BEI NICHTMENSCHLICHEN ZELLEN
Title (fr)
EXPRESSION DE PROTEINES HLA SUR DES CELLULES NON HUMAINES
Publication
Application
Priority
- US 2008000595 W 20080117
- US 88083807 P 20070117
Abstract (en)
[origin: WO2008088837A2] The present invention is directed to a composition that includes a functionally active, individual HLA trimolecular complex expressed on the surface of an immortalized, non- human cell line. Methods of obtaining high expression of the transferred HLA molecule, as well as assays that utilize such recombinant cell line as a platform, are also disclosed. Methods of purifying HLA from such recombinant cell line and methods of using the purified HLA to detect or remove anti-HLA antibodies are also disclosed.
IPC 8 full level
C12N 5/00 (2006.01); C07K 14/00 (2006.01); G01N 33/53 (2006.01); G01N 33/567 (2006.01)
CPC (source: EP)
C07K 14/70539 (2013.01); G01N 33/56977 (2013.01)
Citation (search report)
- No further relevant documents disclosed
- See references of WO 2008088837A2
Designated contracting state (EPC)
AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MT NL NO PL PT RO SE SI SK TR
DOCDB simple family (publication)
WO 2008088837 A2 20080724; WO 2008088837 A3 20081211; AU 2008205526 A1 20080724; EP 2115122 A2 20091111; EP 2115122 A4 20101229; IL 199861 A0 20100415
DOCDB simple family (application)
US 2008000595 W 20080117; AU 2008205526 A 20080117; EP 08724561 A 20080117; IL 19986109 A 20090714