EP 2120880 A2 20091125 - PELLETS COMPRISING AN ACTIVE SUBSTANCE MATRIX RESISTANT TO GASTRIC JUICE
Title (en)
PELLETS COMPRISING AN ACTIVE SUBSTANCE MATRIX RESISTANT TO GASTRIC JUICE
Title (de)
PELLETS MIT MAGENSAFTRESISTENTER WIRKSTOFF-MATRIX
Title (fr)
GRANULES POURVUS D'UNE MATRICE COMPORTANT UNE SUBSTANCE ACTIVE QUI RÉSISTE AU SUC GASTRIQUE
Publication
Application
Priority
- EP 2008050124 W 20080108
- DE 102007009242 A 20070222
Abstract (en)
[origin: WO2008101743A2] The invention relates to pellets having a mean particle size of between 300 and 1100 µm, containing a pharmaceutically active substance integrated into a polymer matrix consisting of at least one water-insoluble polymer. The invention is characterised in that the polymer matrix also contains between 10 and 90 wt. % of an anionic polymer, in the release test according to USP, provided that the pellets release no more than 10 % of the active substance in the artificial gastric juice at a pH of 1.2 after 120 min, and release at least 50 % of the active substance after a total of another 300 min at a pH of 6.8 and/or 7.5.
IPC 8 full level
A61K 9/16 (2006.01); A23L 33/00 (2016.01); A61K 31/522 (2006.01)
CPC (source: EP KR US)
A61K 9/16 (2013.01 - KR); A61K 9/1635 (2013.01 - EP US); A61K 9/1694 (2013.01 - EP US); A61K 31/522 (2013.01 - EP KR US); A61K 47/34 (2013.01 - KR); A61P 1/04 (2017.12 - EP)
Citation (search report)
See references of WO 2008101743A2
Designated contracting state (EPC)
AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MT NL NO PL PT RO SE SI SK TR
DOCDB simple family (publication)
WO 2008101743 A2 20080828; WO 2008101743 A3 20081009; BR PI0807569 A2 20140701; BR PI0807569 A8 20220705; CA 2679010 A1 20080828; CA 2679010 C 20140909; CN 101610755 A 20091223; CN 104490789 A 20150408; DE 102007009242 A1 20080918; EP 2120880 A2 20091125; HK 1205684 A1 20151224; IL 199637 A0 20100415; IL 199637 B 20180131; JP 2010519236 A 20100603; KR 101500769 B1 20150317; KR 20090112717 A 20091028; MX 2009008952 A 20090831; US 2008206350 A1 20080828; US 8216613 B2 20120710
DOCDB simple family (application)
EP 2008050124 W 20080108; BR PI0807569 A 20080108; CA 2679010 A 20080108; CN 200880004035 A 20080108; CN 201410746852 A 20080108; DE 102007009242 A 20070222; EP 08701298 A 20080108; HK 15106221 A 20150630; IL 19963709 A 20090701; JP 2009550250 A 20080108; KR 20097017447 A 20080108; MX 2009008952 A 20080108; US 3494308 A 20080221