Title (en)

USE OF 10-[(3R)-1-AZABICYCLO[2.2.2]OCT-3-YLMETHYL]-10H-PHENOTHIAZINE FOR THE PREPARATION OF A DRUG HAVING A SELECTIVE INHIBITION OF MUSCARINIC M1, M2 AND M3 RECEPTORS

Title (de)

VERWENDUNG VON 10-[(3R)-1-AZABICYCLO[2.2.2]OCT-3-YLMETHYL]-10H-PHENOTHIAZIN FÜR DIE ZUBEREITUNG EINES WIRKSTOFFES MIT SELEKTIVER HEMMUNG DER MUSKARIN-REZEPTOREN M1, M2 UND M3

Title (fr)

UTILISATION DE LA 10-[(3R)-1-AZABICYCLO]2.2.2]OCT-3-YLMÉTHYL]-10H-PHÉNOTHIAZINE POUR LA PRÉPARATION D'UN MÉDICAMENT EXERÇANT UNE INHIBITION SÉLECTIVE DES RÉCEPTEURS MUSCARINIQUES M1, M2 ET M3

Publication

EP 2124956 A1 20091202 (FR)

Application

EP 07858150 A 20071226

Priority

• EP 2007064553 W 20071226
• FR 0656002 A 20061228

Abstract (en)

[origin: FR2910814A1] Use of 10-[(3R)-1-azabicyclo[2.2.2]oct-3-ylmethyl]-10H-phenothiazine (I) and its salts for the manufacture of a medicament to prevent or treat disorders, diseases and/or pathologies by selectively inhibiting of muscarinic M1 receptor, muscarinic M2 receptor and muscarinic M3 receptor, is claimed. ACTIVITY : Uropathic; Antibacterial; Fungicide. MECHANISM OF ACTION : Muscarinic M1 receptor inhibitor; Muscarinic M2 receptor inhibitor; Muscarinic M3 receptor inhibitor. The effect of (I) to inhibit the muscarinic M1 receptor was tested in Chinese hamster ovary cells using in vitro assay. The results showed that (I) exhibited an IC 5 0 value of 1.6 nM.

IPC 8 full level

A61K 31/5415 (2006.01); A61P 13/00 (2006.01)

CPC (source: EP KR US)

A61K 31/5415 (2013.01 - EP KR US); A61P 11/02 (2017.12 - EP); A61P 13/00 (2017.12 - EP); A61P 13/02 (2017.12 - EP); A61P 13/10 (2017.12 - EP); A61P 27/16 (2017.12 - EP); A61P 31/04 (2017.12 - EP); A61P 31/10 (2017.12 - EP); A61P 43/00 (2017.12 - EP)

Citation (search report)

See references of WO 2008080924A1

Citation (examination)

• FENGLEI HUANG ET AL: "Receptor binding studies of soft anticholinergic agents", THE AAPS JOURNAL, vol. 3, no. 4, 1 December 2001 (2001-12-01), pages 44 - 56, XP055053448, ISSN: 1550-7416, DOI: 10.1208/ps030430
• THÜROFF JW, BUNKE B, EBNER A, FABER P, DE GEETER P, HANNAPPEL J, HEIDLER H, MADERSBACHER H, MELCHIOR H, SCHÄFER W, ET AL.: "Randomized, double-blind, multicenter trial on treatment of frequency, urgency and incontinence related to detrusor hyperactivity: oxybutynin versus propantheline versus placebo.", J. UROL, vol. 145, no. 4, April 1991 (1991-04-01), pages 813 - 816

Designated contracting state (EPC)

AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU LV MC MT NL PL PT RO SE SI SK TR

Designated extension state (EPC)

AL BA HR MK RS

DOCDB simple family (publication)

FR 2910814 A1 20080704; FR 2910814 B1 20110617; AR 064714 A1 20090422; AU 2007341274 A1 20080710; AU 2007341274 B2 20120920; BR PI0720591 A2 20140225; CA 2674162 A1 20080710; CN 101573120 A 20091104; CN 101573120 B 20111123; EP 2124956 A1 20091202; FR 2953721 A1 20110617; HK 1133207 A1 20100319; IL 199557 A 20140930; JP 2010514730 A 20100506; JP 5564263 B2 20140730; KR 101465277 B1 20141127; KR 20090103887 A 20091001; MA 31026 B1 20091201; MX 2009006950 A 20090714; NO 20092654 L 20090928; NZ 577915 A 20111222; RU 2009128326 A 20110210; RU 2449794 C2 20120510; TN 2009000257 A1 20101018; TW 200833331 A 20080816; TW I423806 B 20140121; UA 98131 C2 20120425; US 2010063276 A1 20100311; US 8143245 B2 20120327; WO 2008080924 A1 20080710; ZA 200904304 B 20100630

DOCDB simple family (application)

FR 0656002 A 20061228; AR P070105989 A 20071228; AU 2007341274 A 20071226; BR PI0720591 A 20071226; CA 2674162 A 20071226; CN 200780046768 A 20071226; EP 07858150 A 20071226; EP 2007064553 W 20071226; FR 1152199 A 20110317; HK 10100843 A 20100127; IL 19955709 A 20090625; JP 2009543465 A 20071226; KR 20097013047 A 20071226; MA 32046 A 20090626; MX 2009006950 A 20071226; NO 20092654 A 20090713; NZ 57791507 A 20071226; RU 2009128326 A 20071226; TN 2009000257 A 20090623; TW 96147644 A 20071213; UA A200907928 A 20071226; US 52106707 A 20071226; ZA 200904304 A 20090101