Global Patent Index - EP 2125891 A2

EP 2125891 A2 20091202 - ANTAGONIST OX40 ANTIBODIES AND THEIR USE IN THE TREATMENT OF INFLAMMATORY AND AUTOIMMUNE DISEASES

Title (en)

ANTAGONIST OX40 ANTIBODIES AND THEIR USE IN THE TREATMENT OF INFLAMMATORY AND AUTOIMMUNE DISEASES

Title (de)

ANTAGONIST-OX40-ANTIKÖRPER UND IHRE VERWENDUNG BEI DER BEHANDLUNG VON ENTZÜNDLICHEN ERKRANKUNGEN UND AUTOIMMUNKRANKHEITEN

Title (fr)

ANTICORPS ANTAGONISTE D'OX40, ET LEUR UTILISATION DANS LE TRAITEMENT DE MALADIES INFLAMMATOIRES ET AUTO-IMMUNES

Publication

EP 2125891 A2 20091202 (EN)

Application

EP 08726081 A 20080226

Priority

  • US 2008002498 W 20080226
  • US 90369307 P 20070227

Abstract (en)

[origin: WO2008106116A2] The present invention relates to antagonist antibodies directed against human OX40 receptor (CD 134) and fragments thereof, including the amino acid sequences of antagonist antibodies and the nucleic acids that encode the antibodies. Also included in the present invention are antigen binding regions (CDRs) derived from the light and/or heavy chain variable regions of said antibodies. Another aspect of the present invention is the use of anti-OX40 antagonist antibodies in the treatment of inflammatory and autoimmune diseases. The present invention also relates to humanized sequences of an antagonist antibody AlO and epitope mapping of the binding site of the antibody.

IPC 8 full level

C07K 16/28 (2006.01); A61K 39/395 (2006.01); A61P 37/00 (2006.01)

CPC (source: EP KR US)

A61K 39/395 (2013.01 - KR); A61P 1/04 (2017.12 - EP); A61P 1/16 (2017.12 - EP); A61P 3/10 (2017.12 - EP); A61P 7/04 (2017.12 - EP); A61P 7/06 (2017.12 - EP); A61P 9/00 (2017.12 - EP); A61P 11/02 (2017.12 - EP); A61P 11/06 (2017.12 - EP); A61P 17/00 (2017.12 - EP); A61P 17/04 (2017.12 - EP); A61P 19/02 (2017.12 - EP); A61P 21/04 (2017.12 - EP); A61P 25/00 (2017.12 - EP); A61P 25/28 (2017.12 - EP); A61P 27/02 (2017.12 - EP); A61P 29/00 (2017.12 - EP); A61P 37/00 (2017.12 - EP); A61P 37/02 (2017.12 - EP); A61P 37/06 (2017.12 - EP); A61P 37/08 (2017.12 - EP); A61P 43/00 (2017.12 - EP); C07K 16/28 (2013.01 - KR); C07K 16/2878 (2013.01 - EP US); A61K 2039/505 (2013.01 - EP US); C07K 2317/24 (2013.01 - EP US); C07K 2317/56 (2013.01 - EP US); C07K 2317/565 (2013.01 - EP US); C07K 2317/73 (2013.01 - EP US); C07K 2317/76 (2013.01 - EP US); C07K 2317/92 (2013.01 - EP US); C07K 2319/30 (2013.01 - EP US); Y02A 50/30 (2017.12 - EP US)

Citation (search report)

See references of WO 2008106116A2

Citation (examination)

  • WO 9512673 A1 19950511 - UNIV LELAND STANFORD JUNIOR [US], et al
  • IMURA A. ET AL: "The human OX40/gp34 system directly mediates adhesion of activated T cells to vascular endothelial cells", THE JOURNAL OF EXPERIMENTAL MEDICINE, ROCKEFELLER UNIVERSITY PRESS, US, vol. 183, no. 5, 1 May 1996 (1996-05-01), pages 2185 - 2195, XP002589638, ISSN: 0022-1007
  • STÜBER E. ET AL: "The T cell-B cell interaction via OX40-OX40L is necessary for the T cell-dependent humoral immune response", THE JOURNAL OF EXPERIMENTAL MEDICINE, ROCKEFELLER UNIVERSITY PRESS, US LNKD- DOI:10.1084/JEM.183.3.979, vol. 183, no. 3, 1 January 1996 (1996-01-01), pages 979 - 989, XP002255329, ISSN: 0022-1007
  • MORRIS ET AL: "Development and characterization of recombinant human Fc:OX40L fusion protein linked via a coiled-coil trimerization domain", MOLECULAR IMMUNOLOGY, PERGAMON, GB LNKD- DOI:10.1016/J.MOLIMM.2007.02.004, vol. 44, no. 12, 17 April 2007 (2007-04-17), pages 3112 - 3121, XP022031616, ISSN: 0161-5890
  • SALEK-ARDAKANI S. ET AL: "Regulation of CD4 T cell memory by OX40 (CD134)", VACCINE, ELSEVIER LTD, GB LNKD- DOI:10.1016/J.VACCINE.2005.07.108, vol. 24, no. 7, 13 February 2006 (2006-02-13), pages 872 - 883, XP025151914, ISSN: 0264-410X, [retrieved on 20060213]
  • SATAKE Y. ET AL: "Characterization of rat OX40 ligand by monoclonal antibody", BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, ACADEMIC PRESS INC. ORLANDO, FL, US LNKD- DOI:10.1006/BBRC.2000.2560, vol. 270, no. 3, 21 April 2000 (2000-04-21), pages 1041 - 1048, XP002379927, ISSN: 0006-291X

Designated contracting state (EPC)

AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MT NL NO PL PT RO SE SI SK TR

Designated extension state (EPC)

AL BA MK RS

DOCDB simple family (publication)

WO 2008106116 A2 20080904; WO 2008106116 A3 20081016; AR 065506 A1 20090610; AU 2008219666 A1 20080904; BR PI0807269 A2 20140429; CA 2679399 A1 20080904; CL 2008000578 A1 20081010; CN 101668776 A 20100310; CO 6231009 A2 20101220; CR 11042 A 20091103; EC SP099656 A 20091030; EP 2125891 A2 20091202; IL 200572 A0 20100517; JP 2010518873 A 20100603; KR 20100014588 A 20100210; MA 31246 B1 20100301; MX 2009009194 A 20091008; PE 20090689 A1 20090620; RU 2009135824 A 20110410; TW 200846367 A 20081201; US 2010136030 A1 20100603

DOCDB simple family (application)

US 2008002498 W 20080226; AR P080100818 A 20080227; AU 2008219666 A 20080226; BR PI0807269 A 20080226; CA 2679399 A 20080226; CL 2008000578 A 20080226; CN 200880013914 A 20080226; CO 09103883 A 20090923; CR 11042 A 20090924; EC SP099656 A 20090925; EP 08726081 A 20080226; IL 20057209 A 20090825; JP 2009551698 A 20080226; KR 20097020065 A 20080226; MA 32212 A 20090910; MX 2009009194 A 20080226; PE 2008000393 A 20080227; RU 2009135824 A 20080226; TW 97106870 A 20080227; US 52655008 A 20080226