EP 2126118 A4 20100901 - METHOD AND KIT FOR DETECTION OF MBCR/ABL GENE FUSION AND C-KIT (CD117)
Title (en)
METHOD AND KIT FOR DETECTION OF MBCR/ABL GENE FUSION AND C-KIT (CD117)
Title (de)
VERFAHREN UND KIT FÜR DEN NACHWEIS VON MBCR-/ABL-GENFUSION UND C-KIT (CD117)
Title (fr)
PROCEDE ET KIT POUR LA DETECTION DE FUSION DE GENES MBCR/ABL ET DE C-KIT (CD117)
Publication
Application
Priority
- US 2008000958 W 20080124
- US 89716107 P 20070124
Abstract (en)
[origin: WO2008091679A2] Methods and kits for the identification of the major bcr/abl gene fusion and c-kit (CDl 17) expression in patients having or suspected of having a proliferative disorder characterized by the presence of the Mbcr/abl gene fusion and c-kit (CDl 17) expression are disclosed. The method simultaneously detects the presence of Mbcr/abl gene fusion and c-kit (CDl 17) in a biological sample using nucleic acid probes that hybridize to the BCR and ABLl genes, and detects c-kit(CDl 17) positivity. The method and kit can be used to predict the therapeutic efficacy of agents are inhibitors of tyrosine kinase, the BCR/ABL fusion protein c-kit (CDl 17).
IPC 8 full level
C12Q 1/68 (2006.01); C07H 21/04 (2006.01)
CPC (source: EP)
C12Q 1/6886 (2013.01); C12Q 2600/106 (2013.01); C12Q 2600/156 (2013.01)
Citation (search report)
- [I] WO 02093130 A2 20021121 - CANCER GENETICS INC [US], et al
- [I] KATO I ET AL: "Composition for suppressing human Flt-3 function", EMBL,, 21 April 2005 (2005-04-21), XP007914039
- [I] KATO I ET AL: "Composition for suppressing human Flt-3 function", EMBL,, 21 April 2005 (2005-04-21), XP007914038
- See references of WO 2008091679A2
Designated contracting state (EPC)
AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MT NL NO PL PT RO SE SI SK TR
DOCDB simple family (publication)
WO 2008091679 A2 20080731; WO 2008091679 A3 20081224; EP 2126118 A2 20091202; EP 2126118 A4 20100901
DOCDB simple family (application)
US 2008000958 W 20080124; EP 08713271 A 20080124