Title (en)

REAGENTS FOR THE DETECTION OF PROTEIN PHOSPHORYLATION IN LEUKEMIA SIGNALING PATHWAYS

Title (de)

REAGENTIEN ZUM NACHWEIS DER PROTEINPHOSPHORYLIERUNG IN LEUKÄMIE-SIGNALWEGEN

Title (fr)

REACTIFS PERMETTANT DE DETECTER UNE PHOSPHORYLATION DE PROTEINES DANS DES VOIES DE SIGNALISATION DE LEUCEMIE

Publication

EP 2126580 A4 20101110 (EN)

Application

EP 06718094 A 20060112

Priority

• US 2006000979 W 20060112
• US 65158305 P 20050210

Abstract (en)

[origin: WO2006086111A2] The invention discloses 424 novel phosphorylation sites identified in signal transduction proteins and pathways underlying human Leukemia, and provides phosphorylation-site specific antibodies and heavy-isotope labeled peptides (AQUA peptides) for the selective detection and quantification of these phosphorylated sites/proteins, as well as methods of using the reagents for such purpose. Among the phosphorylation sites identified are sites occurring in the following protein types: Adaptor/Scaffold proteins, Cytoskeletal proteins, Cellular Metabolism enzymes, G Protein/GTPase Activating/Guanine Nucleotide Exchange Factor proteins, Immunoglobulin Superfamily proteins, Inhibitor proteins, Lipid Kinases, Nuclear DNA Repair/RNA Binding/Transcription proteins, Serine/Threonine Protein Kinases, Tyrosine Kinases, Protein Phosphatases, and Translation/Transporter proteins.

IPC 8 full level

G01N 33/574 (2006.01)

CPC (source: EP)

C07K 14/47 (2013.01); C07K 16/18 (2013.01); C07K 16/40 (2013.01); C07K 16/44 (2013.01); G01N 33/57426 (2013.01)

Citation (search report)

• [A] WO 03070899 A2 20030828 - CELL SIGNALING TECHNOLOGY INC [US], et al
• See references of WO 2006086111A2

Designated contracting state (EPC)

AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU LV MC NL PL PT RO SE SI SK TR

DOCDB simple family (publication)

WO 2006086111 A2 20060817; WO 2006086111 A3 20090416; EP 2126580 A2 20091202; EP 2126580 A4 20101110

DOCDB simple family (application)

US 2006000979 W 20060112; EP 06718094 A 20060112