EP 2129675 A2 20091209 - DERIVATIVES OF IMIDAZO, PYRIMIDO AND DIAZEPINE PYRIMIDINE-DIONE, AND USE THEREOF AS A DRUG
Title (en)
DERIVATIVES OF IMIDAZO, PYRIMIDO AND DIAZEPINE PYRIMIDINE-DIONE, AND USE THEREOF AS A DRUG
Title (de)
DERIVATE VON IMIDAZO-, PYRIMIDO- UND DIAZEPIN-PYRIMIDIN-DION SOWIE DEREN VERWENDUNG ALS ARZNEIMITTEL
Title (fr)
DÉRIVÉS D'IMIDAZO, PYRIMIDO ET DIAZÉPINE PYRIMIDINE-DIONE ET LEUR UTILISATION COMME MÉDICAMENT
Publication
Application
Priority
- FR 2007002090 W 20071217
- FR 0611001 A 20061218
Abstract (en)
[origin: FR2910001A1] Tricyclic pyrimidone derivatives (I) are new. Tricyclic pyrimidone derivatives of formula (I) are new. L 1CR 3R 4; L 2CR 5R 6; R 1-R 6H, OH, halo, 1-8C alkyl, 1-8C haloalkyl, 2-8C alkenyl, 2-8C alkynyl, 3-8C cycloalkyl, 3-7C heterocycloalkyl, (1-6C)alkoxy(1-8C)alkyl, (1-6C)alkylthio(1-8C)alkyl, aryl, heteroaryl, aralkoxy, aralkylthio or (CH 2) pR 7, all optionally substituted with halo, NO 2, OH, oxo, NH 2, carboxamide, 1-6C alkylcarbonyl, 1-8C alkyl, 1-8C haloalkyl, 1-8C alkoxy, 1-8C haloalkoxy, aryl or aryloxy, or CR 1R 2, CR 3R 4or CR 5R 6is 3-8C cycloalkyl, 3-7C heterocycloalkyl, indanyl, tetrahydronaphthyl or decahydronaphthyl, all optionally substituted with halo, OH, 1-8C alkyl, 1-8C haloalkyl or 1-6C alkoxy, or CR 3R 4+CR 1R 2or CR 3R 4+CR 5R 6is cycloalkenyl, heterocycloalkenyl, aryl or heteroaryl, all optionally substituted with halo, NO 2, OH, NH 2, carboxamide, 1-6C alkylcarbonyl, 1-8C alkyl, 1-8C haloalkyl, 1-8C alkoxy, 1-8C haloalkoxy; p : 1-4; R 71-8C alkoxycarbonyl, CONRR', 3-8C cycloalkyl, 3-7C heterocycloalkyl, aryl or heteroaryl, all optionally substituted with halo, NO 2, OH, NH 2, carboxamide, 1-6C alkylcarbonyl, 1-8C alkyl, 1-8C haloalkyl, 1-8C alkoxy, 1-8C haloalkoxy or aralkoxy; R, R' : H, 1-8C alkyl, 1-8C haloalkyl, 2-8C alkenyl, 2-8C alkynyl, 3-8C cycloalkyl, 3-7C heterocycloalkyl, aryl, heteroaryl, or NRR' is 3-7C heterocycloalkyl; Z : N or CH; Y' : O, CHR 8or NR 8; R 8H, 1-6C alkyl or 1-6C haloalkyl; A : a monocyclic or fused bicyclic ring optionally containing O, S or N and optionally substituted with halo, NO 2, CN, oxy, X'Y' or aryl optionally substituted with halo, 1-6C alkyl and 1-6C haloalkyl; X' : a bond, O, S, CO, NR"CO, CONR", COO, SO 2or SO 2NH; Y' : H, 1-6C alkyl or 1-6C haloalkyl; R" : H or 1-6C alkyl; n, m : 0 or 1. Independent claims are also included for three processes for preparing (I). [Image] ACTIVITY : Cytostatic; Antiinflammatory; Neuroprotective; Antiparkinsonian. MECHANISM OF ACTION : CB2 cannabinoid receptor ligand. Test details are described but no results given.
IPC 8 full level
C07D 487/04 (2006.01); A61K 31/519 (2006.01); A61P 25/00 (2006.01); A61P 35/00 (2006.01)
CPC (source: EP US)
A61P 25/00 (2017.12 - EP); A61P 25/14 (2017.12 - EP); A61P 25/16 (2017.12 - EP); A61P 25/28 (2017.12 - EP); A61P 35/00 (2017.12 - EP); C07D 487/04 (2013.01 - EP US); C07D 487/10 (2013.01 - EP US); C07D 495/14 (2013.01 - EP US)
Citation (search report)
See references of WO 2008090286A2
Designated contracting state (EPC)
AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU LV MC MT NL PL PT RO SE SI SK TR
DOCDB simple family (publication)
FR 2910001 A1 20080620; FR 2910001 B1 20090320; EP 2129675 A2 20091209; US 2010144714 A1 20100610; WO 2008090286 A2 20080731; WO 2008090286 A3 20080918
DOCDB simple family (application)
FR 0611001 A 20061218; EP 07872379 A 20071217; FR 2007002090 W 20071217; US 51964707 A 20071217