EP 2146726 A4 20111102 - DIHYDROPYRIDINE DERIVATIVE FOR TREATING CANCER OR A PRE-CANCEROUS CONDITION AND OTHER CONDITIONS
Title (en)
DIHYDROPYRIDINE DERIVATIVE FOR TREATING CANCER OR A PRE-CANCEROUS CONDITION AND OTHER CONDITIONS
Title (de)
DIHYDROPYRIDIN-DERIVAT ZUR BEHANDLUNG VON KREBS ODER EINER PRÄKANZEROGENEN ERKRANKUNG ODER ANDEREN LEIDEN
Title (fr)
DÉRIVÉ DE DIHYDROPYRIDINE DESTINÉ AU TRAITEMENT D'UN CANCER OU D'UNE AFFECTION PRÉCANCÉREUSE ET D'AUTRES AFFECTIONS
Publication
Application
Priority
- US 2008005731 W 20080502
- US 92730107 P 20070502
Abstract (en)
[origin: WO2008137107A1] The use of dihydropyridine-5-phosphonic acid cyclic propylene ester derivatives of formula (I), a prodrug thereof, or a pharmaceutically acceptable salt of said compound or prodrug in the treatment of cancers, pre-cancerous conditions and other conditions is disclosed, wherein each of R<SUB>1</SUB>-R<SUB>8</SUB> are the same or different, are hydrogen or C<SUB>1</SUB>-C<SUB>6</SUB> alkyl; one of X<SUB>1</SUB> and X<SUB>2</SUB> is nitro while the other is hydrogen; each of Y<SUB>1</SUB> and Y<SUB>2</SUB> may be the same or different, is phenyl which may be substituted by chlorine, fluorine or alkoxy; and m and n are integers from 0-4, a prodrug thereof, or a pharmaceutically acceptable salt thereof.
IPC 8 full level
A61K 31/66 (2006.01); A01N 57/10 (2006.01); A01N 57/36 (2006.01); A61P 3/10 (2006.01); A61P 13/12 (2006.01); A61P 17/02 (2006.01); A61P 25/00 (2006.01); A61P 25/02 (2006.01); A61P 25/08 (2006.01); A61P 27/02 (2006.01); A61P 35/00 (2006.01)
CPC (source: EP US)
A61K 31/66 (2013.01 - EP US); A61P 3/10 (2017.12 - EP); A61P 13/12 (2017.12 - EP); A61P 17/02 (2017.12 - EP); A61P 25/00 (2017.12 - EP); A61P 25/02 (2017.12 - EP); A61P 25/08 (2017.12 - EP); A61P 27/02 (2017.12 - EP); A61P 35/00 (2017.12 - EP); A61P 35/04 (2017.12 - EP)
Citation (search report)
- [X] EP 0353692 A2 19900207 - NISSAN CHEMICAL IND LTD [JP]
- [X] US 2007027194 A1 20070201 - EASTERLING W J [US], et al
- [X] WO 2005086971 A2 20050922 - UNIV MICHIGAN [US], et al
- [Y] EP 1698340 A1 20060906 - NISSAN CHEMICAL IND LTD [JP]
- [Y] EP 1609504 A1 20051228 - NISSAN CHEMICAL IND LTD [JP]
- [X] JP H11246417 A 19990914 - NISSAN CHEMICAL IND LTD, et al
- See references of WO 2008137107A1
Designated contracting state (EPC)
AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MT NL NO PL PT RO SE SI SK TR
DOCDB simple family (publication)
WO 2008137107 A1 20081113; AU 2008248188 A1 20081113; CA 2684938 A1 20081113; EP 2146726 A1 20100127; EP 2146726 A4 20111102; JP 2010526073 A 20100729; US 2010087398 A1 20100408
DOCDB simple family (application)
US 2008005731 W 20080502; AU 2008248188 A 20080502; CA 2684938 A 20080502; EP 08767541 A 20080502; JP 2010506336 A 20080502; US 59849908 A 20080502