EP 2150806 A4 20130102 - METHODS AND SYSTEMS FOR ANALYZING FLUORESCENT MATERIALS WITH REDUCED AUTOFLUORESCENCE
Title (en)
METHODS AND SYSTEMS FOR ANALYZING FLUORESCENT MATERIALS WITH REDUCED AUTOFLUORESCENCE
Title (de)
VERFAHREN UND SYSTEME ZUR ANALYSE VON FLUORESZIERENDEN MATERIALIEN MIT REDUZIERTER EIGENFLUORESZENZ
Title (fr)
PROCÉDÉS ET SYSTÈMES D'ANALYSE DE MATIÈRE FLUORESCENTE À AUTOFLUORESCENCE LIMITÉE
Publication
Application
Priority
- US 2008005953 W 20080509
- US 92861707 P 20070510
- US 90127307 A 20070914
Abstract (en)
[origin: WO2008140758A1] Mitigative and remedial approaches to reduction of autofluorescence background noise are applied in analytical systems that rely upon sensitive measurement of fluorescent signals from arrays of fluorescent signal sources. Such systems are for particular use in fluorescence based sequencing by incorporation systems that rely upon small numbers or individual fluorescent molecules in detecting incorporation of nucleotides in primer extension reactions. Systems and methods for analyzing highly multiplexed sample arrays using highly multiplexed, high-density optical systems to illuminate high- density sample arrays and/or provide detection and preferably confocal detection off signals emanating from such high-density arrays. Systems and methods are applied in a variety of different analytical operations, including analysis of biological and biochemical reactions, including nucleic acid synthesis and derivation of sequence information from such synthesis.
IPC 8 full level
G01N 21/64 (2006.01); G01N 21/76 (2006.01); G01N 24/00 (2006.01); G02B 21/00 (2006.01)
CPC (source: EP)
G01N 21/6452 (2013.01); G01N 27/447 (2013.01); G02B 21/0032 (2013.01); G01N 21/6458 (2013.01)
Citation (search report)
- [Y] US 2004126780 A1 20040701 - RIGLER RUDOLF [CH], et al
- [Y] US 2006214106 A1 20060928 - WOLLESCHENSKY RALF [DE], et al
- [Y] US 2006011859 A1 20060119 - WOLLESCHENSKY RALF [DE], et al
- [A] US 6055106 A 20000425 - GRIER DAVID G [US], et al
- [A] WO 03001178 A2 20030103 - ARRYX INC [US], et al
- [Y] K SVOBODA ET AL: "Biological Applications of Optical Forces", ANNUAL REVIEW OF BIOPHYSICS AND BIOMOLECULAR STRUCTURE, vol. 23, no. 1, 1 June 1994 (1994-06-01), pages 247 - 285, XP055010743, ISSN: 1056-8700, DOI: 10.1146/annurev.bb.23.060194.001335
- [A] GOSCH M ET AL: "Parallel dual-color fluorescence cross-correlation spectroscopy using diffractive optical elements", JOURNAL OF BIOMEDICAL OPTICS SPIE USA, vol. 10, no. 5, September 2005 (2005-09-01), pages 54008 - 1, XP040213852, ISSN: 1083-3668
- See references of WO 2008140758A1
Citation (examination)
JOHANSSON M ET AL: "DESIGN, FABRICATION, AND EVALUATION OF A MULTICHANNEL DIFFRACTIVE OPTIC ROTARY JOINT", APPLIED OPTICS, OPTICAL SOCIETY OF AMERICA, WASHINGTON, DC; US, vol. 38, no. 8, 10 March 1999 (1999-03-10), pages 1302 - 1310, XP000823450, ISSN: 0003-6935, DOI: 10.1364/AO.38.001302
Designated contracting state (EPC)
AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MT NL NO PL PT RO SE SI SK TR
DOCDB simple family (publication)
WO 2008140758 A1 20081120; AU 2008251861 A1 20081120; AU 2008251861 B2 20140320; CA 2687062 A1 20081120; CA 2687062 C 20160412; EP 2150806 A1 20100210; EP 2150806 A4 20130102
DOCDB simple family (application)
US 2008005953 W 20080509; AU 2008251861 A 20080509; CA 2687062 A 20080509; EP 08767652 A 20080509