EP 2155173 A1 20100224 - MODIFIED-RELEASE PARTICLES BASED ON POLYELECTROLYTES AND ON AN ACTIVE PRINCIPLE AND PHARMACEUTICAL FORMULATIONS CONTAINING THESE PARTICLES
Title (en)
MODIFIED-RELEASE PARTICLES BASED ON POLYELECTROLYTES AND ON AN ACTIVE PRINCIPLE AND PHARMACEUTICAL FORMULATIONS CONTAINING THESE PARTICLES
Title (de)
TEILCHEN MIT MODIFIZIERTER FREISETZUNG AUF BASIS VON POLYELEKTROLYTEN UND AUF EINEM WIRKSTOFF SOWIE DIESE TEILCHEN ENTHALTENDE PHARMAZEUTISCHE FORMULIERUNGEN
Title (fr)
PARTICULES A BASE DE POLYELECTROLYTES ET DE PRINCIPE ACTIF A LIBERATION MODIFIEE ET FORMULATIONS PHARMACEUTIQUES CONTENANT CES PARTICULES
Publication
Application
Priority
- EP 2008055505 W 20080505
- FR 0703187 A 20070503
Abstract (en)
[origin: WO2008135561A1] The present invention relates to novel polyelectrolyte polymer particles for transporting an active principle (AP), in particular a protein and peptide active principle, and also to novel modified-release pharmaceutical formulations containing said AP microparticles. These novel AP-loaded particles release the AP over a prolonged duration of several days, or even several weeks. The invention relates, in a first aspect, to particles comprising: a) a first polyelectrolyte polymer (PE1) in the charged state, bearing side hydrophobic groups (HG), said first polyelectrolyte polymer (PE1) spontaneously forming, in water, a colloidal solution of particles at at least a value pHm of the pH between 3 and 8; b) a second polyelectrolyte polymer (PE2) of opposite polarity to that of the first polyelectrolyte polymer (PE1), said second polyelectrolyte polymer (PE2) forming, in water, a solution or a colloidal solution at at least said pHm value of the pH; c) at least one active principle (AP) combined non-covalently with the particles of the colloidal solution of the first polyelectrolyte polymer (PE1); said particles being obtained by mixing, at a pH equal to pHm, of the first polyelectrolyte polymer (PE1) in the form of a colloidal solution of particles combined with the active principle (AP) with the second polyelectrolyte polymer (PE2) in the form of a solution or a colloidal solution. The invention also relates to the process for preparing these particles, a pharmaceutical formulation comprising such particles and a process for preparing medications.
IPC 8 full level
CPC (source: EP KR US)
A61K 9/14 (2013.01 - KR); A61K 9/16 (2013.01 - KR); A61K 9/1641 (2013.01 - EP US); A61K 9/5146 (2013.01 - EP US); A61K 47/34 (2013.01 - KR)
Citation (search report)
See references of WO 2008135561A1
Designated contracting state (EPC)
AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MT NL NO PL PT RO SE SI SK TR
Designated extension state (EPC)
AL BA MK RS
DOCDB simple family (publication)
FR 2915684 A1 20081107; FR 2915684 B1 20110114; AU 2008248602 A1 20081113; AU 2008248602 B2 20120726; BR PI0810878 A2 20141029; CA 2685855 A1 20081113; CN 101674814 A 20100317; CN 101674814 B 20131016; EP 2155173 A1 20100224; IL 201689 A0 20100531; IL 201689 A 20130829; JP 2010526040 A 20100729; KR 20100017574 A 20100216; MX 2009011815 A 20091113; US 2009011039 A1 20090108; US 8481019 B2 20130709; WO 2008135561 A1 20081113
DOCDB simple family (application)
FR 0703187 A 20070503; AU 2008248602 A 20080505; BR PI0810878 A 20080505; CA 2685855 A 20080505; CN 200880014547 A 20080505; EP 08750062 A 20080505; EP 2008055505 W 20080505; IL 20168909 A 20091022; JP 2010504755 A 20080505; KR 20097025178 A 20080505; MX 2009011815 A 20080505; US 14955208 A 20080505