EP 2162743 A4 20100714 - METHODS OF MODULATING INFLAMMATION AND COMPOSITIONS THEREFORE
Title (en)
METHODS OF MODULATING INFLAMMATION AND COMPOSITIONS THEREFORE
Title (de)
VERFAHREN ZUR MODULATION VON ENTZÜNDUNG UND ZUSAMMENSETZUNGEN DAFÜR
Title (fr)
PROCEDES DE MODULATION DE L'INFLAMMATION ET COMPOSITIONS ASSOCIEES
Publication
Application
Priority
- US 2008006728 W 20080528
- US 93209507 P 20070529
Abstract (en)
[origin: WO2008153790A2] The present invention provides compositions and methods useful for detecting or treating asthma or other allergic or inflammatory diseases. In one aspect, the methods of the invention include modulating an IL-13/sIL-13Ra2 complex and methods of modulating expression of various nucleotide sequences of interest including Pira1, Vannin1 and ApoA1. In an aspect, the methods of the invention allow detection of an altered IL-13/sIL-13Ra2 complex level in a subject. Further aspects of the invention allow for identification of subjects suitable for inclusion in a sIL-13Ra2 related study or inflammatory related disorder study.
IPC 8 full level
G01N 33/53 (2006.01); C07K 16/00 (2006.01)
CPC (source: EP)
C07K 16/244 (2013.01); C07K 16/2866 (2013.01); G01N 33/6869 (2013.01); A61K 38/00 (2013.01); G01N 2333/5437 (2013.01); G01N 2800/24 (2013.01)
Citation (search report)
- [X] WO 0036103 A1 20000622 - GENETICS INST [US], et al
- [A] US 2004247524 A1 20041209 - NAQUET PHILIPPE [FR], et al
- [A] JP 2005095166 A 20050414 - SUMITOMO PHARMA
- [XP] KHODOUN MARAT ET AL: "Differences in expression, affinity, and function of soluble (s)IL-4R alpha and sIL-13R alpha 2 suggest opposite effects on allergic responses", JOURNAL OF IMMUNOLOGY, vol. 179, no. 10, November 2007 (2007-11-01), pages 6429 - 6438, XP002583463, ISSN: 0022-1767
- [A] DATABASE EMBL [online] 13 December 2002 (2002-12-13), "Mus musculus adult male stomach cDNA, RIKEN full-length enriched library, clone:2210421G13 product:hypothetical protein, full insert sequence.", XP002583464, retrieved from EBI accession no. EMBL:AK075855 Database accession no. AK075855
- See references of WO 2008153790A2
Designated contracting state (EPC)
AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MT NL NO PL PT RO SE SI SK TR
DOCDB simple family (publication)
WO 2008153790 A2 20081218; WO 2008153790 A3 20090305; CA 2688256 A1 20081218; EP 2162743 A2 20100317; EP 2162743 A4 20100714
DOCDB simple family (application)
US 2008006728 W 20080528; CA 2688256 A 20080528; EP 08767898 A 20080528