EP 2166560 A1 20100324 - Maldi matrices
Title (en)
Maldi matrices
Title (de)
Maldi-Matrizen
Title (fr)
Matrices Maldi
Publication
Application
Priority
EP 08016619 A 20080922
Abstract (en)
The present invention relates to novel MALDI matrices for the analysis of low-molecular-weight compounds in both positive and negative ion mode. In addition, the present invention relates to the rational selection of the MALDI matrices for predetermined analytes, a process which has remained empirical since the invention of the technique. In another aspect, the present invention provides a new, fast and high-throughput method for analyzing low-molecular-weight compounds by MALDI analysis as well as systems therefore.
IPC 8 full level
H01J 49/16 (2006.01); G01N 33/68 (2006.01)
CPC (source: EP)
H01J 49/164 (2013.01)
Citation (applicant)
WEI J. ET AL., NATURE, vol. 399, 1999, pages 234 - 246
Citation (search report)
- [A] DE 10238069 A1 20040304 - NUTRICIA NV [NL]
- [X] "RÖMPP Online", December 2006, THIEME CHEMISTRY, XP002515537
- [X] SNOVIDA SERGEI I ET AL: "A 2,5-dihydroxybenzoic acid/N,N-dimethylaniline matrix for the analysis of oligosaccharides by matrix-assisted laser desorption/ionization mass spectrometry", RAPID COMMUNICATIONS IN MASS SPECTROMETRY, vol. 21, no. 22, 2007, pages 3711 - 3715, XP002515535, ISSN: 0951-4198
- [X] FUKUYAMA Y ET AL: "Rapid sequencing and disulfide mapping of peptides containing disulfide bonds by using 1,5-diaminonaphthalene as a reductive matrix", JOURNAL OF MASS SPECTROMETRY 200602 GB, vol. 41, no. 2, February 2006 (2006-02-01), pages 191 - 201, XP002515536, ISSN: 1076-5174 1096-9888
- [Y] KRAUSE J ET AL: "Studies on the selection of new matrices for ultraviolet matrix-assisted laser desorption/ionization time-of-flight mass spectrometry.", RAPID COMMUNICATIONS IN MASS SPECTROMETRY : RCM 1996, vol. 10, no. 15, 1996, pages 1927 - 1933, XP002530718, ISSN: 0951-4198
- [Y] TAKAYAM M: "N-C alpha bond cleavage of the peptide backbone via hydrogen abstraction", JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY, ELSEVIER SCIENCE INC, US, vol. 12, no. 9, 1 September 2001 (2001-09-01), pages 1044 - 1049, XP004319586, ISSN: 1044-0305
Designated contracting state (EPC)
AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MT NL NO PL PT RO SE SI SK TR
Designated extension state (EPC)
AL BA MK RS
DOCDB simple family (publication)
EP 2166560 A1 20100324; WO 2010031588 A2 20100325; WO 2010031588 A3 20100826
DOCDB simple family (application)
EP 08016619 A 20080922; EP 2009006838 W 20090922