EP 2167525 A2 20100331 - 17ß-CYANO-19-ANDROST-4-ENE DERIVATIVE, USE THEREOF AND MEDICAMENTS CONTAINING SAID DERIVATIVE
Title (en)
17ß-CYANO-19-ANDROST-4-ENE DERIVATIVE, USE THEREOF AND MEDICAMENTS CONTAINING SAID DERIVATIVE
Title (de)
17ß-CYANO-19-ANDROST-4-EN-DERIVAT, DESSEN VERWENDUNG UND DAS DERIVAT ENTHALTENDE ARZNEIMITTEL
Title (fr)
DÉRIVÉ DE 17 -CYANO-19-ANDROST-4-ÈNE, SON UTILISATION, ET MÉDICAMENT CONTENANT CE DÉRIVÉ
Publication
Application
Priority
- EP 2008057427 W 20080612
- DE 102007027635 A 20070612
- US 94365107 P 20070613
Abstract (en)
[origin: US2010292184A1] The 17β-cyano-19-androst-4-ene derivatives of the present invention possess gestagenic activity. They have the general chemical formula 1, in which Z is selected from the group comprising O, two hydrogen atoms, NOR and NNHSO2R, in which R is hydrogen or C1-C4-alkyl, R1, R2 are each independently hydrogen or methyl, or R1 and R2 together form methylene or are omitted with formation of a double bond between C1 and C2, R4 is hydrogen or halogen, furthermore either: R6a, R6b together form methylene or 1,2-ethanediyl or R6a is hydrogen and R6b is selected from the group comprising hydrogen, methyl and hydroxymethylene, and R7 is selected from the group comprising hydrogen, C1-C4-alkyl, C2-C3-alkenyl and cyclopropyl, or: R6a hydrogen and R6b and R7 together form methylene or are omitted with formation of a double bond between C6 and C7 or: R6a is methyl and R6b and R7 are omitted with formation of a double bond between C6 and C7, R15, R16 are hydrogen or together form methylene, R17 is selected from the group comprising hydrogen, C1-C4-alkyl and allyl, and moreover comprise their solvates, hydrates, stereoisomers, diastereomers, enantiomers and salts, with the proviso that particular compounds are excluded.
IPC 8 full level
C07J 53/00 (2006.01); C07J 41/00 (2006.01)
CPC (source: EP US)
A61P 5/24 (2017.12 - EP); A61P 5/34 (2017.12 - EP); A61P 5/42 (2017.12 - EP); A61P 15/08 (2017.12 - EP); A61P 15/12 (2017.12 - EP); A61P 15/18 (2017.12 - EP); C07J 41/0094 (2013.01 - EP US); C07J 53/007 (2013.01 - EP US); C07J 53/008 (2013.01 - EP US)
Citation (search report)
See references of WO 2008152112A2
Designated contracting state (EPC)
AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MT NL NO PL PT RO SE SI SK TR
Designated extension state (EPC)
AL BA MK RS
DOCDB simple family (publication)
US 2010292184 A1 20101118; AU 2008263857 A1 20081218; BR PI0812535 A2 20170516; CA 2692997 A1 20081218; CL 2008001720 A1 20081219; CN 101679479 A 20100324; DE 102007027635 A1 20081218; EP 2167525 A2 20100331; IL 202325 A0 20100630; JP 2010529174 A 20100826; KR 20100037596 A 20100409; MX 2009013631 A 20100120; RU 2010100337 A 20110720; WO 2008152112 A2 20081218; WO 2008152112 A3 20090430; ZA 201000186 B 20110330
DOCDB simple family (application)
US 66409908 A 20080612; AU 2008263857 A 20080612; BR PI0812535 A 20080612; CA 2692997 A 20080612; CL 2008001720 A 20080611; CN 200880020030 A 20080612; DE 102007027635 A 20070612; EP 08760962 A 20080612; EP 2008057427 W 20080612; IL 20232509 A 20091125; JP 2010511650 A 20080612; KR 20107000606 A 20080612; MX 2009013631 A 20080612; RU 2010100337 A 20080612; ZA 201000186 A 20100111