Global Patent Index - EP 2172486 A3

EP 2172486 A3 20120229 - Monoclonal antibody against a prion protein and its use for the detection of prions

Title (en)

Monoclonal antibody against a prion protein and its use for the detection of prions

Title (de)

Monoklonaler Antikörper gegen ein Prion und dessen Verwendung zum Nachweis von Prionen

Title (fr)

Anticorps monoclonal contre un prion et son utilisation pour la détection de prions

Publication

EP 2172486 A3 20120229 (EN)

Application

EP 09010591 A 19980218

Previously filed application

PCT/EP98/00917 19980218 WO

Priority

  • EP 98910699 A 19980218
  • EP 97102837 A 19970221
  • EP 09010591 A 19980218

Abstract (en)

[origin: US6765088B1] The presented invention relates to monoclonal antibodies useful in sensitive and specific immunological assays for the identification of prions in various tissues and body fluids, the production of such monoclonal antibodies by means of immunization of PrP<0/0 >mice by means of a new recombinant fragment of PrP and the use of the antibodies, e.g. for therapeutic and preventive treatments of humans and animals suffering from prion diseases.

IPC 8 full level

C07K 16/28 (2006.01); A61K 39/395 (2006.01); C07K 14/47 (2006.01); C07K 16/18 (2006.01); C12N 1/21 (2006.01); C12N 5/10 (2006.01); C12N 5/20 (2006.01); C12N 15/06 (2006.01); C12N 15/70 (2006.01); G01N 33/577 (2006.01); G01N 33/68 (2006.01); A61K 38/00 (2006.01)

CPC (source: EP US)

C07K 14/47 (2013.01 - EP US); C07K 16/2872 (2013.01 - EP US); A61K 38/00 (2013.01 - EP US); C07K 2317/34 (2013.01 - EP US)

Citation (search report)

  • [XI] WO 9311155 A1 19930610 - PROTEUS MOLECULAR DESIGN [GB]
  • [A] WO 9323432 A1 19931125 - UNIV NEW YORK [US], et al
  • [A] S. KRASEMANN ET AL.: "Induction of antibodies against human prion proteins (PrP) by DNA-mediated immunization of PrP0/0 mice.", JOURNAL OF IMMUNOLOGICAL METHODS, vol. 199, no. 2, 15 December 1996 (1996-12-15), AMSTERDAM, pages 109 - 118, XP002036869
  • [A] C. KORTH ET AL.: "Characterization of native and recombinant prion protein isoforms by differential exposure of antibody epitopes.", SOCIETY FOR NEUROSCIENCE, ABSTRACTS, vol. 22, no. 1-3, 16 November 1996 (1996-11-16) - 21 November 1996 (1996-11-21), pages 2159, XP002036864
  • [A] R. KASCSAK ET AL.: "The role of antibodies to PrP in the diagnosis of transmissible spongiform encephalopathies.", DEVELOPMENTS IN BIOLOGICAL STANDARDIZATION, vol. 80, 1993, BASEL, pages 141 - 151, XP002036865
  • [XP] C. KORTH ET AL.: "Prion (PrPsc)-specific epitope defined by a monoclonal antibody.", NATURE, vol. 390, no. 6655, 6 November 1997 (1997-11-06), England, pages 74 - 77, XP002069611

Designated contracting state (EPC)

AT BE CH DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE

Designated extension state (EPC)

LT LV RO SI

DOCDB simple family (publication)

US 6765088 B1 20040720; AT E440868 T1 20090915; AU 6498698 A 19980909; AU 742838 B2 20020110; CA 2280791 A1 19980827; CA 2280791 C 20110621; DE 69841102 D1 20091008; EP 0861900 A1 19980902; EP 1007700 A1 20000614; EP 1007700 B1 20090826; EP 2172486 A2 20100407; EP 2172486 A3 20120229; EP 2172486 B1 20141105; NZ 336656 A 20020531; US 2006025575 A1 20060202; US 7259246 B2 20070821; WO 9837210 A1 19980827

DOCDB simple family (application)

US 38001599 A 19990823; AT 98910699 T 19980218; AU 6498698 A 19980218; CA 2280791 A 19980218; DE 69841102 T 19980218; EP 09010591 A 19980218; EP 97102837 A 19970221; EP 9800917 W 19980218; EP 98910699 A 19980218; NZ 33665698 A 19980218; US 86758904 A 20040615