EP 2172563 A1 20100407 - Method for lowering the dependency towards sequence variation of a nucleic acid target in a diagnostic hybridization assay
Title (en)
Method for lowering the dependency towards sequence variation of a nucleic acid target in a diagnostic hybridization assay
Title (de)
Verfahren zur Verringerung der Abhängigkeit von Sequenzvariationen eines Nukleinsäuretargets in einem diagnostischen Hybridisierungs-Assay
Title (fr)
Procédé pour diminuer la dépendance envers la variation de séquence d'une cible d'acide nucléique dans une analyse d'hybridation de diagnostic
Publication
Application
Priority
EP 08016733 A 20080924
Abstract (en)
The present invention provides primer or/and probe, this target sequence containing at least one variation, defined as either one non-conserved nucleotide, called genotype variation, or one nucleotide variation within one and the same genotype, wherein the primer or/and probe comprises a nucleic acid sequence that is complementary to said target sequence except for the at least complementary base of the variation(s), which is not present in the primer or/and probe. The present invention is especially useful in methods for diagnostic, preventive and therapeutic applications.
IPC 8 full level
C12Q 1/68 (2006.01)
CPC (source: EP US)
C12Q 1/6876 (2013.01 - EP US); C12Q 2600/156 (2013.01 - EP US)
Citation (applicant)
- EP 1426448 A1 20040609 - BIOMERIEUX BV [NL]
- EP 0246864 B1 19940713 - BIO RAD LABORATORIES [US]
- EP 0329822 B1 19940608 - CANGENE CORP [CA]
- EP 1366179 A2 20031203 - BIOMERIEUX BV [NL]
- FR 2607507 A1 19880603 - CENTRE NAT RECH SCIENT [FR]
- US 4683195 A 19870728 - MULLIS KARY B [US], et al
- US 4683202 A 19870728 - MULLIS KARY B [US]
- US 4800159 A 19890124 - MULLIS KARY B [US], et al
- EP 0569272 B1 19980617 - BIO MERIEUX [FR]
- WO 9001069 A1 19900208 - SEGEV DIAGNOSTICS INC [US]
- WO 9006995 A1 19900628 - SISKA DIAGNOSTICS INC [US]
- WO 9102818 A1 19910307 - CANGENE CORP [CA]
- US 5399491 A 19950321 - KACIAN DANIEL L [US], et al
- PIATEK ET AL., NATURE BIOTECHNOLOGY, vol. 16, 1998, pages 359 - 363
- TYAGI; KRAMER, NATURE BIOTECHNOLOGY, vol. 14, 1996, pages 303 - 308
- M. EGHOLM ET AL., J. AM. CHEM. SOC., vol. 114, 1992, pages 1895 - 1897
Citation (search report)
- [Y] EP 1426448 A1 20040609 - BIOMERIEUX BV [NL]
- [Y] EP 0246864 A2 19871125 - ICI PLC [GB]
- [Y] WO 9710364 A1 19970320 - DGI INC [US]
- [A] EP 1659187 A1 20060524 - BIOMERIEUX BV [NL]
- [A] EP 1531183 A1 20050518 - BIOMERIEUX BV [NL]
Designated contracting state (EPC)
AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MT NL NO PL PT RO SE SI SK TR
Designated extension state (EPC)
AL BA MK RS
DOCDB simple family (publication)
EP 2172563 A1 20100407; CN 102165077 A 20110824; EP 2334822 A2 20110622; JP 2012503472 A 20120209; US 2011236892 A1 20110929; WO 2010034690 A2 20100401; WO 2010034690 A3 20100610
DOCDB simple family (application)
EP 08016733 A 20080924; CN 200980137630 A 20090921; EP 09783245 A 20090921; EP 2009062206 W 20090921; JP 2011527347 A 20090921; US 200913058979 A 20090921