EP 2173886 A4 20101013 - INFLUENZA VIRUS-LIKE PARTICLES (VLPS) COMPRISING HEMAGGLUTININ PRODUCED WITHIN A PLANT
Title (en)
INFLUENZA VIRUS-LIKE PARTICLES (VLPS) COMPRISING HEMAGGLUTININ PRODUCED WITHIN A PLANT
Title (de)
INFLUENZA-VIRUS-ÄHNLICHE PARTIKEL (VLPS) MIT IN EINER PFLANZE PRODUZIERTEM HÄMAGGLUTININ
Title (fr)
PSEUDO-PARTICULES DU VIRUS DE LA GRIPPE (VLP) COMPRENANT DE L'HÉMAGGLUTININE (HA) PRODUIT DANS UNE PLANTE
Publication
Application
Priority
- CA 2008001281 W 20080711
- US 95941407 P 20070713
- US 99060307 P 20071127
- US 1327207 P 20071212
- CA 2615372 A 20080121
- US 2277508 P 20080122
Abstract (en)
[origin: WO2009009876A1] A method for synthesizing influenza virus-like particles (VLPs) within a plant or a portion of a plant is provided. The method involves expression of influenza HA in plants and the purification by size exclusion chromatography. The invention is also directed towards a VLP comprising influenza HA protein and plants lipids. The invention is also directed to a nucleic acid encoding influenza HA as well as vectors. The VLPs may be used to formulate influenza vaccines, or may be used to enrich existing vaccines.
IPC 8 full level
C12N 15/82 (2006.01); A61K 39/145 (2006.01); A61P 31/16 (2006.01); A61P 37/04 (2006.01); C07K 14/11 (2006.01); C12N 7/01 (2006.01); C12N 7/02 (2006.01); C12N 15/29 (2006.01); C12N 15/44 (2006.01)
CPC (source: EP KR US)
A61K 39/12 (2013.01 - EP US); A61K 39/145 (2013.01 - EP KR US); A61P 31/00 (2017.12 - EP); A61P 31/16 (2017.12 - EP); A61P 37/00 (2017.12 - EP); A61P 37/04 (2017.12 - EP); C07K 14/005 (2013.01 - EP US); C07K 14/11 (2013.01 - KR); C12N 7/00 (2013.01 - EP US); C12N 9/90 (2013.01 - US); C12N 15/82 (2013.01 - KR); C12N 15/8257 (2013.01 - EP US); C12N 15/8258 (2013.01 - EP US); C12Y 503/04001 (2013.01 - US); G06F 9/505 (2013.01 - US); A61K 2039/517 (2013.01 - EP US); A61K 2039/5258 (2013.01 - EP US); A61K 2039/543 (2013.01 - EP US); A61K 2039/55505 (2013.01 - EP US); A61K 2039/55583 (2013.01 - EP US); A61K 2039/55588 (2013.01 - US); A61K 2039/58 (2013.01 - EP US); C07K 2319/02 (2013.01 - US); C07K 2319/03 (2013.01 - US); C12N 2760/16022 (2013.01 - US); C12N 2760/16122 (2013.01 - EP US); C12N 2760/16123 (2013.01 - EP US); C12N 2760/16133 (2013.01 - US); C12N 2760/16134 (2013.01 - EP US); C12N 2760/16151 (2013.01 - US); C12N 2760/16171 (2013.01 - US); C12N 2760/16222 (2013.01 - US); C12N 2760/16223 (2013.01 - US); C12N 2760/16234 (2013.01 - US); G06F 2209/508 (2013.01 - US)
Citation (search report)
- [XY] WO 2004098533 A2 20041118 - THOMPSON BOYCE PLANT RES [US], et al
- [XY] MUSIYCHUK KONSTANTIN ET AL: "A launch vector for the production of vaccine antigens in plants", INFLUENZA AND OTHER RESPIRATORY VIRUSES, BLACKWELL PUBLISHING LTD, UK LNKD- DOI:10.1111/J.1750-2659.2006.00005.X, vol. 1, no. 1, 1 January 2007 (2007-01-01), pages 19 - 25, XP009058889, ISSN: 1750-2640, [retrieved on 20070119]
- [Y] PUSHKO ET AL: "Influenza virus-like particles comprised of the HA, NA, and M1 proteins of H9N2 influenza virus induce protective immune responses in BALB/c mice", VACCINE, ELSEVIER LTD, GB LNKD- DOI:10.1016/J.VACCINE.2005.07.098, vol. 23, no. 50, 30 December 2005 (2005-12-30), pages 5751 - 5759, XP005180698, ISSN: 0264-410X
- [Y] GRGACIC E V L ET AL: "Virus-like particles: Passport to immune recognition", METHODS : A COMPANION TO METHODS IN ENZYMOLOGY, ACADEMIC PRESS INC., NEW YORK, NY, US LNKD- DOI:10.1016/J.YMETH.2006.07.018, vol. 40, no. 1, 1 September 2006 (2006-09-01), pages 60 - 65, XP024908472, ISSN: 1046-2023, [retrieved on 20060901]
- [Y] SAINT-JORE-DUPAS ET AL: "From planta to pharma with glycosylation in the toolbox", TRENDS IN BIOTECHNOLOGY, ELSEVIER PUBLICATIONS, CAMBRIDGE, GB, vol. 25, no. 7, 1 July 2007 (2007-07-01), pages 317 - 323, XP022116342, ISSN: 0167-7799
- [XP] D'AOUST MARC-ANDRÉ ET AL: "Influenza virus-like particles produced by transient expression in Nicotiana benthamiana induce a protective immune response against a lethal viral challenge in mice.", PLANT BIOTECHNOLOGY JOURNAL DEC 2008 LNKD- PUBMED:19076615, vol. 6, no. 9, December 2008 (2008-12-01), pages 930 - 940, XP002598510, ISSN: 1467-7644
- [T] D'AOUST MARC-ANDRE ET AL: "The production of hemagglutinin-based virus-like particles in plants: a rapid, efficient and safe response to pandemic influenza", PLANT BIOTECHNOLOGY JOURNAL, vol. 8, no. 5, June 2010 (2010-06-01), pages 607 - 619, XP002598511, ISSN: 1467-7644
- See references of WO 2009009876A1
Designated contracting state (EPC)
AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MT NL NO PL PT RO SE SI SK TR
Designated extension state (EPC)
MK RS
DOCDB simple family (publication)
WO 2009009876 A1 20090122; AU 2008278222 A1 20090122; AU 2008278222 B2 20140306; CA 2615372 A1 20090113; CA 2693956 A1 20090122; CA 2693956 C 20130924; CN 101883856 A 20101110; CN 101883856 B 20131030; CR 11209 A 20100323; DK 2173886 T3 20130930; EA 018206 B1 20130628; EA 201000195 A1 20101029; EP 2173886 A1 20100414; EP 2173886 A4 20101013; EP 2173886 B1 20130626; ES 2428384 T3 20131107; JP 2010533001 A 20101021; JP 5624465 B2 20141112; KR 101541330 B1 20150805; KR 20100032920 A 20100326; MX 2010000525 A 20100427; MY 155236 A 20150930; NZ 582360 A 20120427; PL 2173886 T3 20131231; PT 2173886 E 20130903; SI 2173886 T1 20131129; TN 2009000557 A1 20110331; US 2010239610 A1 20100923; US 2011293650 A1 20111201; US 2013183341 A1 20130718; US 2023044454 A1 20230209; US 9452210 B2 20160927; US 9492528 B2 20161115
DOCDB simple family (application)
CA 2008001281 W 20080711; AU 2008278222 A 20080711; CA 2615372 A 20080121; CA 2693956 A 20080711; CN 200880107072 A 20080711; CR 11209 A 20100111; DK 08783201 T 20080711; EA 201000195 A 20080711; EP 08783201 A 20080711; ES 08783201 T 20080711; JP 2010516334 A 20080711; KR 20107002538 A 20080711; MX 2010000525 A 20080711; MY PI20100142 A 20080711; NZ 58236008 A 20080711; PL 08783201 T 20080711; PT 08783201 T 20080711; SI 200831024 T 20080711; TN 2009000557 A 20091231; US 200913003570 A 20090702; US 201313734886 A 20130104; US 202217815503 A 20220727; US 66903308 A 20080711