EP 2177502 A1 20100421 - Compounds and their use
Title (en)
Compounds and their use
Title (de)
Verbindungen und ihre Verwendung
Title (fr)
Composants et leur utilisation
Publication
Application
Priority
EP 08166973 A 20081017
Abstract (en)
Compounds of formula (I) wherein each of R1-R5 is independently selected, may be optionally substituted, and is chosen from -H, halo, alkyl, alkoxy, haloalkyl, haloalkoxy, -L-aryl, -L-heteroaryl, -L-heterocycle, -L-carbocycle, acylamino, acyloxy, alkylthio, alkynyl, amino, aryl, arylalkyl, arylalkenyl, arylalkynyl, arylalkoxy, aryloxy, arylthio, cyano, cyanato, haloaryl, hydroxyl, heteroaryloxy, heteroarylalkoxy, isocyanato, isothiocyanato, nitro, sulfinyl, sulfonyl, sulfonamide, thiocarbonyl, thiocyanato, trihalomethanesulfonamido, O-carbamyl, N-carbamyl, O-thiocarbamyl, N-thiocarbamyl, and C-amido; R6 is chosen from -H and alkyl; R7 is chosen from -H, alkyl, and cycloalkyl; R8 is chosen from -C(=O)NR x R y and -C(=O)R z ; and pharmaceutically acceptable salts thereof, are useful in therapy.
IPC 8 full level
C07C 229/10 (2006.01); A61K 31/165 (2006.01); A61K 31/167 (2006.01); A61K 31/223 (2006.01); A61K 31/5375 (2006.01); A61P 35/00 (2006.01); C07C 237/04 (2006.01); C07D 295/192 (2006.01)
CPC (source: EP)
A61P 35/00 (2017.12); C07C 229/14 (2013.01); C07C 237/04 (2013.01); C07C 237/06 (2013.01); C07D 295/192 (2013.01); C07C 2601/02 (2017.04)
Citation (applicant)
- US 4522811 A 19850611 - EPPSTEIN DEBORAH A [US], et al
- FERLAY ET AL., ANN. ONCOL., vol. 18, no. 3, 2007, pages 581 - 92
- SHI ET AL., CELL, vol. 119, 2004, pages 941
- KAHL ET AL., CANCER RES., vol. 66, 2006, pages 1341 - 11347
- REDDY ET AL., CIRC. RES., vol. 103, 2008, pages 615
- LEE ET AL., CHEM. BIOL., vol. 13, 2006, pages 563 - 567
- GOODEN ET AL., BIOORG. MED. CHEM. LET., vol. 18, 2008, pages 3047 - 3051
- HUANG ET AL., PNAS, vol. 104, 2007, pages 8023 - 8028
- B. BURGER ET AL., J. MED. CHEM., vol. 5, 1962, pages 1243 - 1265
- ZIRKLE ET AL., J. MED. CHEM., 1962, pages 1265 - 1284
- BROWN ET AL., ANN. REV. MED, vol. 39, 1988, pages 221 - 229
- WILSON ET AL., J. CLIN. PSYCH., vol. 45, 1984, pages 242 - 247
- PHILLIPS ET AL., J. PHARMACEUT. SCI., vol. 73, 1984, pages 1718 - 1720
- BURNHAM, AM. J. HOSP. PHARM., vol. 15, 1994, pages 210 - 218
Citation (search report)
- [X] US 2005009832 A1 20050113 - SUN CONNIE LI [US], et al
- [X] US 2006275366 A1 20061207 - MALCOLM BRUCE A [US], et al
- [X] WO 2007025709 A2 20070308 - NOVARTIS AG [CH], et al
- [X] US 2006287287 A1 20061221 - GERRITZ SAMUEL [US], et al
- [X] WO 2004062601 A2 20040729 - CHIRON CORP [US], et al
- [A] EP 1704859 A1 20060927 - UNIVERSITAETSKLINIKUM FREIBURG [DE]
Designated contracting state (EPC)
AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MT NL NO PL PT RO SE SI SK TR
Designated extension state (EPC)
AL BA MK RS
DOCDB simple family (publication)
DOCDB simple family (application)
EP 08166973 A 20081017