Global Patent Index - EP 2177502 A1

EP 2177502 A1 20100421 - Compounds and their use

Title (en)

Compounds and their use

Title (de)

Verbindungen und ihre Verwendung

Title (fr)

Composants et leur utilisation

Publication

EP 2177502 A1 20100421 (EN)

Application

EP 08166973 A 20081017

Priority

EP 08166973 A 20081017

Abstract (en)

Compounds of formula (I) wherein each of R1-R5 is independently selected, may be optionally substituted, and is chosen from -H, halo, alkyl, alkoxy, haloalkyl, haloalkoxy, -L-aryl, -L-heteroaryl, -L-heterocycle, -L-carbocycle, acylamino, acyloxy, alkylthio, alkynyl, amino, aryl, arylalkyl, arylalkenyl, arylalkynyl, arylalkoxy, aryloxy, arylthio, cyano, cyanato, haloaryl, hydroxyl, heteroaryloxy, heteroarylalkoxy, isocyanato, isothiocyanato, nitro, sulfinyl, sulfonyl, sulfonamide, thiocarbonyl, thiocyanato, trihalomethanesulfonamido, O-carbamyl, N-carbamyl, O-thiocarbamyl, N-thiocarbamyl, and C-amido; R6 is chosen from -H and alkyl; R7 is chosen from -H, alkyl, and cycloalkyl; R8 is chosen from -C(=O)NR x R y and -C(=O)R z ; and pharmaceutically acceptable salts thereof, are useful in therapy.

IPC 8 full level

C07C 229/10 (2006.01); A61K 31/165 (2006.01); A61K 31/167 (2006.01); A61K 31/223 (2006.01); A61K 31/5375 (2006.01); A61P 35/00 (2006.01); C07C 237/04 (2006.01); C07D 295/192 (2006.01)

CPC (source: EP)

A61P 35/00 (2017.12); C07C 229/14 (2013.01); C07C 237/04 (2013.01); C07C 237/06 (2013.01); C07D 295/192 (2013.01); C07C 2601/02 (2017.04)

Citation (applicant)

  • US 4522811 A 19850611 - EPPSTEIN DEBORAH A [US], et al
  • FERLAY ET AL., ANN. ONCOL., vol. 18, no. 3, 2007, pages 581 - 92
  • SHI ET AL., CELL, vol. 119, 2004, pages 941
  • KAHL ET AL., CANCER RES., vol. 66, 2006, pages 1341 - 11347
  • REDDY ET AL., CIRC. RES., vol. 103, 2008, pages 615
  • LEE ET AL., CHEM. BIOL., vol. 13, 2006, pages 563 - 567
  • GOODEN ET AL., BIOORG. MED. CHEM. LET., vol. 18, 2008, pages 3047 - 3051
  • HUANG ET AL., PNAS, vol. 104, 2007, pages 8023 - 8028
  • B. BURGER ET AL., J. MED. CHEM., vol. 5, 1962, pages 1243 - 1265
  • ZIRKLE ET AL., J. MED. CHEM., 1962, pages 1265 - 1284
  • BROWN ET AL., ANN. REV. MED, vol. 39, 1988, pages 221 - 229
  • WILSON ET AL., J. CLIN. PSYCH., vol. 45, 1984, pages 242 - 247
  • PHILLIPS ET AL., J. PHARMACEUT. SCI., vol. 73, 1984, pages 1718 - 1720
  • BURNHAM, AM. J. HOSP. PHARM., vol. 15, 1994, pages 210 - 218

Citation (search report)

Designated contracting state (EPC)

AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MT NL NO PL PT RO SE SI SK TR

Designated extension state (EPC)

AL BA MK RS

DOCDB simple family (publication)

EP 2177502 A1 20100421

DOCDB simple family (application)

EP 08166973 A 20081017