Global Patent Index - EP 2178565 A1

EP 2178565 A1 20100428 - COMPLEXES BETWEEN AN AMPHIPHILIC POLYMER AND AN OSTEOGENIC PROTEIN OF THE BMPS FAMILY

Title (en)

COMPLEXES BETWEEN AN AMPHIPHILIC POLYMER AND AN OSTEOGENIC PROTEIN OF THE BMPS FAMILY

Title (de)

KOMPLEXE ZWISCHEN EINEM AMPHIPHILEN POLYMER UND EINEM OSTEOGENEN PROTEIN DER BMPS-FAMILIE

Title (fr)

COMPLEXES ENTRE UN POLYMÈRE AMPHIPHILE ET UNE PROTÉINE OSTÉOGÉNIQUE APPARTENANT À LA FAMILLE DES BMPs

Publication

EP 2178565 A1 (FR)

Application

EP 08786481 A

Priority

  • EP 2008059832 W
  • FR 0705536 A
  • US 95240707 P

Abstract (en)

[origin: WO2009016131A1] The invention relates to a physically and chemically stable, water-soluble amphiphilic polymer-BMP complex, characterised in that: the amphiphilic polymers include a hydrophilic polysaccharide skeleton functionalised by hydrophobic substituants and hydrophilic groups; the BMP is selected from the group of therapeutically active BMPs (Bone morphogenetic Proteins); the polymer/BMP mass ratio is lower than or equal to 700. The invention also relates to a method for preparing the amphiphilic polymer-BMP complex in an aqueous medium in the absence of any solvent capable of denaturing the protein. The invention further relates to therapeutic compositions of the amphiphilic polymer-BMP complex of the invention.

IPC 8 full level

A61K 47/36 (2006.01); A61K 38/18 (2006.01)

CPC (source: EP)

A61K 9/0019 (2013.01); A61K 38/1875 (2013.01); A61K 47/36 (2013.01); A61K 47/61 (2017.08); A61P 19/00 (2018.01); A61P 19/08 (2018.01); C08B 11/12 (2013.01); C08B 15/00 (2013.01); C08B 37/0021 (2013.01); C08B 37/003 (2013.01); C08B 37/0045 (2013.01); C08B 37/0069 (2013.01); C08B 37/0072 (2013.01); C08B 37/0084 (2013.01)

Designated contracting state (EPC)

AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MT NL NO PL PT RO SE SI SK TR

Designated extension state (EPC)

AL BA MK RS

DOCDB simple family (publication)

FR 2919188 A1 20090130; FR 2919188 B1 20100226; AU 2008281848 A1 20090205; CA 2694600 A1 20090205; CN 101835493 A 20100915; EP 2178565 A1 20100428; JP 2010534708 A 20101111; KR 20100051695 A 20100517; MX 2010001104 A 20100401; RU 2010107203 A 20110910; US 2009048412 A1 20090219; US 8389661 B2 20130305; WO 2009016131 A1 20090205; ZA 201001163 B 20101027

DOCDB simple family (application)

FR 0705536 A 20070727; AU 2008281848 A 20080725; CA 2694600 A 20080725; CN 200880107383 A 20080725; EP 08786481 A 20080725; EP 2008059832 W 20080725; JP 2010518637 A 20080725; KR 20107004494 A 20080725; MX 2010001104 A 20080725; RU 2010107203 A 20080725; US 21967908 A 20080725; ZA 201001163 A 20100217