EP 2179045 A2 20100428 - CARTILAGE-SPECIFIC EXPRESSION
Title (en)
CARTILAGE-SPECIFIC EXPRESSION
Title (de)
KNORPELSPEZIFISCHE EXPRESSION
Title (fr)
EXPRESSION SPÉCIFIQUE AU CARTILAGE
Publication
Application
Priority
- IB 2008052638 W 20080701
- HU P0700457 A 20070703
Abstract (en)
[origin: WO2009004575A2] The invention provides an isolated nucleic acid comprising a nucleotide sequence for cartilage-specific expression, said sequence comprising the proximal promoter region of the matrilin-1 promoter and at least two cartilage-specific distal control elements capable of binding Sox9 positioned in 5' direction relative to the said proximal promoter region element. Vectors and transgenic animals are also provided.
IPC 8 full level
C12N 15/85 (2006.01); A01K 67/027 (2006.01)
CPC (source: EP)
A01K 67/0275 (2013.01); C07K 14/78 (2013.01); C12N 15/8509 (2013.01); A01K 2217/05 (2013.01); A01K 2227/105 (2013.01); A01K 2267/0393 (2013.01); C12N 2830/008 (2013.01)
Citation (examination)
- Y HAN ET AL: "L-Sox5 and Sox6 Drive Expression of the Aggrecan Gene in Cartilage by Securing Binding of Sox9 to a Far-Upstream Enhancer", MOLECULAR AND CELLULAR BIOLOGY,, vol. 28, no. 16, 16 June 2008 (2008-06-16), pages 4999 - 5013, XP055036856
- TOSHIYUKI IKEDA ET AL: "Distinct roles of Sox5, Sox6, and Sox9 in different stages of chondrogenic differentiation", JOURNAL OF BONE AND MINERAL METABOLISM, SPRINGER-VERLAG, TO, vol. 23, no. 5, 1 September 2005 (2005-09-01), pages 337 - 340, XP019373810, ISSN: 1435-5604, DOI: 10.1007/S00774-005-0610-Y
Designated contracting state (EPC)
AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MT NL NO PL PT RO SE SI SK TR
Designated extension state (EPC)
AL BA MK RS
DOCDB simple family (publication)
WO 2009004575 A2 20090108; WO 2009004575 A3 20090305; EP 2179045 A2 20100428; HU 0700457 D0 20070828; HU 227614 B1 20110928; HU P0700457 A2 20090528
DOCDB simple family (application)
IB 2008052638 W 20080701; EP 08763428 A 20080701; HU P0700457 A 20070703