Global Patent Index - EP 2185560 A4

EP 2185560 A4 20111005 - HETEROARYL AMIDE ANALOGUES

Title (en)

HETEROARYL AMIDE ANALOGUES

Title (de)

HETEROARYLAMIDANALOGE

Title (fr)

ANALOGUES D'HÉTÉROARYLAMIDES

Publication

EP 2185560 A4 20111005 (EN)

Application

EP 08797591 A 20080811

Priority

  • US 2008072760 W 20080811
  • US 95525007 P 20070810

Abstract (en)

[origin: WO2009023623A1] Compounds, pharmaceutical compositions, and methods of use are disclosed for heteroaryl amide analogues of formula Ia and/or Ib: . In certain embodiments, the heteroaryl amide analogues are agonists and/or ligands of dopamine receptors and may be useful, inter alia, for the treatment of a condition responsive to P2X7 receptor modulation, for example, pain, inflammation, a neurological or neurodegenerative disorder, a cardiovascular disorder, an ocular disorder or an immune system disorder.

IPC 8 full level

C07D 401/04 (2006.01); A61K 31/506 (2006.01); A61P 25/02 (2006.01); C07D 401/12 (2006.01); C07D 401/14 (2006.01); C07D 403/04 (2006.01); C07D 471/04 (2006.01)

CPC (source: EP KR)

A61P 1/16 (2017.12 - EP); A61P 11/00 (2017.12 - EP); A61P 11/06 (2017.12 - EP); A61P 25/02 (2017.12 - EP); A61P 25/04 (2017.12 - EP); A61P 25/28 (2017.12 - EP); A61P 27/02 (2017.12 - EP); A61P 27/06 (2017.12 - EP); A61P 29/00 (2017.12 - EP); A61P 43/00 (2017.12 - EP); C07D 401/04 (2013.01 - EP); C07D 401/12 (2013.01 - EP); C07D 401/14 (2013.01 - EP); C07D 403/04 (2013.01 - EP KR); C07D 471/04 (2013.01 - EP); C07D 487/04 (2013.01 - KR)

Citation (search report)

  • [X] US 2003199689 A1 20031023 - NAZARE MARC [DE], et al
  • [X] US 2005165049 A1 20050728 - HULME CHRISTOPHER [US], et al
  • [X] WO 2006100208 A1 20060928 - ORGANON NV [NL], et al
  • [X] US 2007149602 A1 20070628 - DUBOIS LAURENT [FR], et al
  • [X] WO 2006072736 A1 20060713 - SANOFI AVENTIS [FR], et al
  • [X] WO 2005009947 A2 20050203 - AVENTIS PHARMA SA [FR]
  • [X] WO 2004056768 A2 20040708 - BAYER HEALTHCARE AG [DE], et al
  • [X] US 5424329 A 19950613 - BOSCHELLI DIANE H [US], et al
  • [X] US 5399559 A 19950321 - CURTZE JUERGEN [DE], et al
  • [X] US 4803198 A 19890207 - OHLENDORF HEINRICH-WILHELM [DE], et al
  • [X] US 4374846 A 19830222 - HEINEMANN HENNING [DE], et al
  • [X] EP 1310488 A1 20030514 - MITSUBISHI PHARMA CORP [JP]
  • [I] WO 2005014529 A1 20050217 - ASTRAZENECA AB [SE], et al
  • [XI] NAZARE ET AL.: "Probing the Subpockets of Factor Xa Reveals Two Binding Modes for Inhibitors Based on a 2-Carboxyindole Scaffold: A Study Combining Structure-Activity Relationship and X-ray Crystallography", J. MED. CHEM., vol. 48, no. 14, 1 January 2005 (2005-01-01), pages 4511 - 4525, XP002546715, ISSN: 0022-2623, [retrieved on 20050611], DOI: 10.1021/JM0490540
  • [XI] BRANDS ET AL.: "Novel, selective indole-based ECE inhibitors: Lead optimization via solid-phase and classical synthesis", BIOORG. MED. CHEM. LETT., vol. 15, no. 19, 1 October 2005 (2005-10-01), pages 4201 - 4205, XP027388767, ISSN: 0960-894X, [retrieved on 20050830]
  • [XI] NAZARE ET AL.: "Factor Xa inhibitors based on a 2-carboxyindole scaffold: SAR of neutral P1 substituents", BIOORG. MED. CHEM. LETT., vol. 14, no. 16, 1 May 2004 (2004-05-01), pages 4191 - 4195, XP002546716, ISSN: 0960-894X, DOI: 10.1016/J.BMCL.2004.06.020
  • [XI] OELGEN ET AL.: "Synthesis and antioxidant properties of novel N-substituted indole-2-carboxamide and indole-3-acetamide derivatives", ARCHIV DER PHARMAZIE, vol. 7, 1 January 2002 (2002-01-01), pages 331 - 338, XP002275101, ISSN: 0365-6233, DOI: 10.1002/1521-4184(200209)335:7<331::AID-ARDP331>3.0.CO;2-7
  • [XI] CONNOR ET AL.: "Novel Benzothiophene-, Benzofuran-, and Naphthalenecarboxamidotetraz oles as Potential Antiallergy Agents", J. MED. CHEM., vol. 35, 1 January 1992 (1992-01-01), pages 958 - 965, XP002303235, ISSN: 0022-2623, DOI: 10.1021/JM00083A023
  • See references of WO 2009023623A1

Designated contracting state (EPC)

AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MT NL NO PL PT RO SE SI SK TR

Designated extension state (EPC)

AL BA MK RS

DOCDB simple family (publication)

WO 2009023623 A1 20090219; AU 2008286946 A1 20090219; AU 2008286946 B2 20131121; BR PI0812594 A2 20150623; CA 2691512 A1 20090219; CN 101778850 A 20100714; CO 6251319 A2 20110221; EA 020332 B1 20141030; EA 200971085 A1 20100630; EP 2185560 A1 20100519; EP 2185560 A4 20111005; IL 202550 A0 20100630; JP 2010535816 A 20101125; JP 2015110566 A 20150618; KR 20100066422 A 20100617; NZ 582056 A 20120831; SG 183699 A1 20120927; UA 99729 C2 20120925

DOCDB simple family (application)

US 2008072760 W 20080811; AU 2008286946 A 20080811; BR PI0812594 A 20080811; CA 2691512 A 20080811; CN 200880021498 A 20080811; CO 09146587 A 20091222; EA 200971085 A 20080811; EP 08797591 A 20080811; IL 20255009 A 20091206; JP 2010520343 A 20080811; JP 2014238138 A 20141125; KR 20097026704 A 20080811; NZ 58205608 A 20080811; SG 2012058533 A 20080811; UA A200913336 A 20080811