Global Patent Index - EP 2186822 A1

EP 2186822 A1 20100519 - Use of inhibitors of Plac8 activity for the modulation of adipogenesis

Title (en)

Use of inhibitors of Plac8 activity for the modulation of adipogenesis

Title (de)

Verwendung von Inhibitoren der Plac8-Aktivität zur Modulation von Adipogenese

Title (fr)

Utilisation d'inhibiteurs d'activité Plac8 pour la modulation de l'adipogenèse

Publication

EP 2186822 A1 20100519 (EN)

Application

EP 08291041 A 20081107

Priority

EP 08291041 A 20081107

Abstract (en)

The present invention concerns Plac8, a new target involved in adipogenesis modulation. Using a siRNA approach, the inventors demonstrated that decrease in Plac8 activity in preadipocytes and adipose tissue induces a decrease in adipogenesis. Thus, the present invention relates to modulators of Plac8 activity as well as screening test for identification of modulators of the activity of this target, and their use, especially in pharmaceutical composition, to modulate adipogenesis and thus treat obesity and related disorders.

IPC 8 full level

C07K 14/47 (2006.01); A61K 38/57 (2006.01)

CPC (source: EP KR US)

A61K 38/57 (2013.01 - KR); A61P 3/00 (2017.12 - EP); A61P 3/04 (2017.12 - EP); A61P 3/06 (2017.12 - EP); A61P 3/10 (2017.12 - EP); A61P 9/00 (2017.12 - EP); A61P 9/12 (2017.12 - EP); A61P 43/00 (2017.12 - EP); C07K 14/47 (2013.01 - KR); C07K 14/4715 (2013.01 - EP US); C12N 15/113 (2013.01 - EP US); C12N 2310/14 (2013.01 - EP US)

Citation (applicant)

  • US 5795715 A 19980818 - LIVACHE THIERRY [FR], et al
  • DE FOURMESTRAUX ET AL., J. BIOL. CHEM., vol. 279, 2004, pages 50743 - 53
  • BANERJEE, S. S. ET AL.: "The Kruppel-like factor KLF2 inhibits peroxisome proliferator-activated receptor-gamma expression and adipogenesis", J BIOL CHEM., vol. 278, 7 November 2002 (2002-11-07), pages 2581 - 4
  • CHEN, Z. ET AL.: "Krox20 stimulates adipogenesis via C/EBPbeta-dependent and -independent mechanisms", CELL METAB., vol. 2, 2005, pages 93 - 106
  • COLLINS, S. ET AL.: "Genetic vulnerability to diet-induced obesity in the C57BL/6J mouse: physiological and molecular characteristics", PHYSIOL BEHAV, vol. 81, 2004, pages 243 - 8
  • DE FOURMESTRAUX V ET AL.: "Transcript profiling suggests that differential metabolic adaptation of mice to a high fat diet is associated with changes in liver to muscle lipid fluxes", J. BIOL. CHEM, vol. 279, 2004, pages 50743 - 53, XP055059290, DOI: doi:10.1074/jbc.M408014200
  • GRAY, S. ET AL.: "The Kruppel-like factor KLF15 regulates the insulin-sensitive glucose transporter GLUT4", J BIOL CHEM, vol. 277, 2002, pages 34322 - 8, XP002469581
  • JIMENEZ, M. A. ET AL.: "Critical role for Ebf1 and Ebf2 in the adipogenic transcriptional cascade", MOL CELL BIOL, vol. 27, 2007, pages 743 - 57
  • KANG, S. ET AL.: "Wnt signaling stimulates osteoblastogenesis of mesenchymal precursors by suppressing CCAAT/enhancer-binding protein alpha and peroxisome proliferator-activated receptor gamma", J BIOL CHEM, vol. 282, 2007, pages 14515 - 24
  • LEDFORD, J. G.; M. KOVAROVA; B. H. KOLLER.: "Impaired host defense in mice lacking ONZIN", J IMMUNOL, vol. 178, 2007, pages 5132 - 43, XP002487076
  • ROGULSKI, K. ET AL.: "Onzin, a c-Myc-repressed target, promotes survival and transformation by modulating the Akt-Mdm2-p53 pathway", ONCOGENE, vol. 24, 2005, pages 7524 - 41, XP002487074, DOI: doi:10.1038/sj.onc.1208897
  • BHATTACHARYYA A; MURCHIE AI; LILLEY DM.: "RNA bulges and the helical periodicity of double-stranded RNA", NATURE, vol. 343, no. 6257, 1 February 1990 (1990-02-01), pages 484 - 7

Citation (search report)

  • [A] GALAVIZ-HERNANDEZ C ET AL: "Plac8 and Plac9, novel placental-enriched genes identified through microarray analysis", GENE, ELSEVIER, AMSTERDAM, NL, vol. 309, no. 2, 8 May 2003 (2003-05-08), pages 81 - 89, XP004426685, ISSN: 0378-1119
  • [A] FEVE ET AL: "Adipogenesis: cellular and molecular aspects", BAILLIERE'S BEST PRACTICE AND RESEARCH. CLINICAL ENDOCRINOLOGYAND METABOLISM, BAILLIERE TINDALL, LONDON, GB, vol. 19, no. 4, 1 December 2005 (2005-12-01), pages 483 - 499, XP005177205, ISSN: 1521-690X
  • [A] MACDOUGALD O A ET AL: "Adipogenesis: forces that tip the scales", TRENDS IN ENDOCRINOLOGY AND METABOLISM, ELSEVIER SCIENCE PUBLISHING, NEW YORK, NY, US, vol. 13, no. 1, 1 January 2002 (2002-01-01), pages 5 - 11, XP002964520, ISSN: 1043-2760

Designated contracting state (EPC)

AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MT NL NO PL PT RO SE SI SK TR

Designated extension state (EPC)

AL BA MK RS

DOCDB simple family (publication)

EP 2186822 A1 20100519; AR 074295 A1 20110105; AU 2009312476 A1 20100514; BR PI0921274 A2 20181016; CA 2742770 A1 20100514; CN 102203128 A 20110928; EP 2364324 A1 20110914; IL 212667 A0 20110731; JP 2012508224 A 20120405; KR 20110093840 A 20110818; MX 2011004852 A 20110606; US 2012035241 A1 20120209; WO 2010052581 A1 20100514

DOCDB simple family (application)

EP 08291041 A 20081107; AR P090104294 A 20091106; AU 2009312476 A 20091105; BR PI0921274 A 20091105; CA 2742770 A 20091105; CN 200980144014 A 20091105; EP 09774724 A 20091105; IB 2009007630 W 20091105; IL 21266711 A 20110503; JP 2011535185 A 20091105; KR 20117012750 A 20091105; MX 2011004852 A 20091105; US 200913127841 A 20091105